Abstract
We studied trifluoromethane as a potential gaseous indicator in nuclear magnetic resonance measurements of cerebral blood flow. We considered the effects of trifluoromethane on cerebral blood flow in 17 cats and on the electroencephalogram and electrocardiogram in nine cats and compared these with the effects of the more toxic compound chlorodifluoromethane in five cats. Inhaled at 60%, trifluoromethane had no effect on cerebral blood flow, the cerebral metabolic rate for oxygen, or oxyhemoglobin content. At 70%, trifluoromethane sensitized the cats' hearts to epinephrine, but to a much lesser degree than 40% chlorodifluoromethane, and produced only moderate changes in cerebral electrical activity as measured by the electroencephalogram. We found trifluoromethane to be suitable for use in animals, but its toxicity needs to be studied further before it can be used in humans for the measurement of cerebral blood flow.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1172-1177 |
| Number of pages | 6 |
| Journal | Stroke |
| Volume | 21 |
| Issue number | 8 |
| State | Published - 1990 |
| Externally published | Yes |
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Keywords
- Cats
- Cerebral blood flow
- Nuclear magnetic resonance
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Clinical Neurology
- Advanced and Specialized Nursing
- Neuroscience(all)
Cite this
Acute toxicity of a nuclear magnetic resonance cerebral blood flow indicator in cats. / Branch, Craig A.; Ewing, James R.; Fagan, Susan C.; Goldberg, David A.; Welch, K.
In: Stroke, Vol. 21, No. 8, 1990, p. 1172-1177.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute toxicity of a nuclear magnetic resonance cerebral blood flow indicator in cats
AU - Branch, Craig A.
AU - Ewing, James R.
AU - Fagan, Susan C.
AU - Goldberg, David A.
AU - Welch, K.
PY - 1990
Y1 - 1990
N2 - We studied trifluoromethane as a potential gaseous indicator in nuclear magnetic resonance measurements of cerebral blood flow. We considered the effects of trifluoromethane on cerebral blood flow in 17 cats and on the electroencephalogram and electrocardiogram in nine cats and compared these with the effects of the more toxic compound chlorodifluoromethane in five cats. Inhaled at 60%, trifluoromethane had no effect on cerebral blood flow, the cerebral metabolic rate for oxygen, or oxyhemoglobin content. At 70%, trifluoromethane sensitized the cats' hearts to epinephrine, but to a much lesser degree than 40% chlorodifluoromethane, and produced only moderate changes in cerebral electrical activity as measured by the electroencephalogram. We found trifluoromethane to be suitable for use in animals, but its toxicity needs to be studied further before it can be used in humans for the measurement of cerebral blood flow.
AB - We studied trifluoromethane as a potential gaseous indicator in nuclear magnetic resonance measurements of cerebral blood flow. We considered the effects of trifluoromethane on cerebral blood flow in 17 cats and on the electroencephalogram and electrocardiogram in nine cats and compared these with the effects of the more toxic compound chlorodifluoromethane in five cats. Inhaled at 60%, trifluoromethane had no effect on cerebral blood flow, the cerebral metabolic rate for oxygen, or oxyhemoglobin content. At 70%, trifluoromethane sensitized the cats' hearts to epinephrine, but to a much lesser degree than 40% chlorodifluoromethane, and produced only moderate changes in cerebral electrical activity as measured by the electroencephalogram. We found trifluoromethane to be suitable for use in animals, but its toxicity needs to be studied further before it can be used in humans for the measurement of cerebral blood flow.
KW - Cats
KW - Cerebral blood flow
KW - Nuclear magnetic resonance
UR - http://www.scopus.com/inward/record.url?scp=0025118141&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025118141&partnerID=8YFLogxK
M3 - Article
C2 - 2389297
AN - SCOPUS:0025118141
VL - 21
SP - 1172
EP - 1177
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 8
ER -