Acute toxicity of a nuclear magnetic resonance cerebral blood flow indicator in cats

Craig A. Branch, James R. Ewing, Susan C. Fagan, David A. Goldberg, K. Welch

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We studied trifluoromethane as a potential gaseous indicator in nuclear magnetic resonance measurements of cerebral blood flow. We considered the effects of trifluoromethane on cerebral blood flow in 17 cats and on the electroencephalogram and electrocardiogram in nine cats and compared these with the effects of the more toxic compound chlorodifluoromethane in five cats. Inhaled at 60%, trifluoromethane had no effect on cerebral blood flow, the cerebral metabolic rate for oxygen, or oxyhemoglobin content. At 70%, trifluoromethane sensitized the cats' hearts to epinephrine, but to a much lesser degree than 40% chlorodifluoromethane, and produced only moderate changes in cerebral electrical activity as measured by the electroencephalogram. We found trifluoromethane to be suitable for use in animals, but its toxicity needs to be studied further before it can be used in humans for the measurement of cerebral blood flow.

Original languageEnglish (US)
Pages (from-to)1172-1177
Number of pages6
JournalStroke
Volume21
Issue number8
DOIs
StatePublished - Aug 1990
Externally publishedYes

Keywords

  • Cats
  • Cerebral blood flow
  • Nuclear magnetic resonance

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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