Acute stimulation of glucose metabolism in mice by leptin treatment

Seika Kamohara, Rémy Burcelin, Jeffrey L. Halaas, Jeffrey M. Friedman, Maureen J. Charron

Research output: Contribution to journalArticle

579 Citations (Scopus)

Abstract

Leptin is an adipocyte hormone that functions as an afferent signal in a negative feedback loop regulating body weight, and acts by interacting with a receptor in the hypothalamus and other tissues. Leptin treatment has potent effects on lipid metabolism, and leads to a large, specific reduction of adipose tissue mass after several days. Here we show that leptin also acts acutely to increase glucose metabolism, although studies of leptin's effect on glucose metabolism have typically been confounded by the weight-reducing actions of leptin treatment, which by itself could affect glucose homoeostasis. We have demonstrated acute in vivo effects of intravenous and intracerebroventricular administrations of leptin on glucose metabolism. A five-hour intravenous infusion of leptin into wild-type mice increased glucose turnover and glucose uptake, but decreased hepatic glycogen content. The plasma levels of insulin and glucose did not change. Similar effects were observed after both intravenous and intracerebroventricular infusion of leptin, suggesting that effects of leptin on glucose metabolism are mediated by the central nervous system (CNS). These data indicate that leptin induces a complex metabolic response with effects on glucose as well as lipid metabolism. This response is unique to leptin, which suggests that new efferent signals emanate from the CNS after leptin treatment.

Original languageEnglish (US)
Pages (from-to)374-377
Number of pages4
JournalNature
Volume389
Issue number6649
DOIs
StatePublished - 1997

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Leptin
Glucose
Therapeutics
Lipid Metabolism
Intravenous Infusions
Central Nervous System
Intraventricular Infusions
Liver Glycogen
Adipocytes
Intravenous Administration
Hypothalamus
Adipose Tissue
Homeostasis
Body Weight
Hormones
Insulin
Weights and Measures

ASJC Scopus subject areas

  • General

Cite this

Kamohara, S., Burcelin, R., Halaas, J. L., Friedman, J. M., & Charron, M. J. (1997). Acute stimulation of glucose metabolism in mice by leptin treatment. Nature, 389(6649), 374-377. https://doi.org/10.1038/38717

Acute stimulation of glucose metabolism in mice by leptin treatment. / Kamohara, Seika; Burcelin, Rémy; Halaas, Jeffrey L.; Friedman, Jeffrey M.; Charron, Maureen J.

In: Nature, Vol. 389, No. 6649, 1997, p. 374-377.

Research output: Contribution to journalArticle

Kamohara, S, Burcelin, R, Halaas, JL, Friedman, JM & Charron, MJ 1997, 'Acute stimulation of glucose metabolism in mice by leptin treatment', Nature, vol. 389, no. 6649, pp. 374-377. https://doi.org/10.1038/38717
Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ. Acute stimulation of glucose metabolism in mice by leptin treatment. Nature. 1997;389(6649):374-377. https://doi.org/10.1038/38717
Kamohara, Seika ; Burcelin, Rémy ; Halaas, Jeffrey L. ; Friedman, Jeffrey M. ; Charron, Maureen J. / Acute stimulation of glucose metabolism in mice by leptin treatment. In: Nature. 1997 ; Vol. 389, No. 6649. pp. 374-377.
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