Acute response of social functioning in dysthymic patients with desipramine

Richard A. Friedman; John C. Markowitz; Michael Parides; James H. Kocsis

doi:10.1016/0165-0327(95)00003-6

Acute response of social functioning in dysthymic patients with desipramine

Richard A. Friedman, John C. Markowitz, Michael Parides, James H. Kocsis

Research output: Contribution to journal › Article

37 Scopus citations

Abstract

Despite some evidence that short-term antidepressant treatment improves social dysfunction in depressed patients, little is known about the response of specific social impairments in dysthymic patients to antidepressant medication. We examined the effect of acute (10 weeks), open-label desipramine (DMI) treatment on social functioning in subjects with DSM-III-R dysthymia. Social functioning was assessed with the social adjustment scale self-report (SAS-SR) at baseline and at week 10. Compared with DMI nonresponders, DMI responders showed significantly greater improvement in overall social functioning (F_2,45 = 5.46, P < 0.0001) and in enjoyment of leisure time (F_2,45 = 14.38, P < 0.0001) on the SAS-SR. Dysthymic patients who respond to DMI improve significantly in social functioning. Diminished capacity to enjoy leisure time may be a state marker of depression in some chronically depressed patients.

Original language	English (US)
Pages (from-to)	85-88
Number of pages	4
Journal	Journal of Affective Disorders
Volume	34
Issue number	2
DOIs	https://doi.org/10.1016/0165-0327(95)00003-6
State	Published - May 17 1995
Externally published	Yes

Keywords

Desipramine
Dysthymia
Social functioning

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

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Friedman, R. A., Markowitz, J. C., Parides, M., & Kocsis, J. H. (1995). Acute response of social functioning in dysthymic patients with desipramine. Journal of Affective Disorders, 34(2), 85-88. https://doi.org/10.1016/0165-0327(95)00003-6

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abstract = "Despite some evidence that short-term antidepressant treatment improves social dysfunction in depressed patients, little is known about the response of specific social impairments in dysthymic patients to antidepressant medication. We examined the effect of acute (10 weeks), open-label desipramine (DMI) treatment on social functioning in subjects with DSM-III-R dysthymia. Social functioning was assessed with the social adjustment scale self-report (SAS-SR) at baseline and at week 10. Compared with DMI nonresponders, DMI responders showed significantly greater improvement in overall social functioning (F2,45 = 5.46, P < 0.0001) and in enjoyment of leisure time (F2,45 = 14.38, P < 0.0001) on the SAS-SR. Dysthymic patients who respond to DMI improve significantly in social functioning. Diminished capacity to enjoy leisure time may be a state marker of depression in some chronically depressed patients.",

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