Acute response of social functioning in dysthymic patients with desipramine

Richard A. Friedman; John C. Markowitz; Michael Parides; James H. Kocsis

doi:10.1016/0165-0327(95)00003-6

Acute response of social functioning in dysthymic patients with desipramine

Richard A. Friedman, John C. Markowitz, Michael Parides, James H. Kocsis

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Despite some evidence that short-term antidepressant treatment improves social dysfunction in depressed patients, little is known about the response of specific social impairments in dysthymic patients to antidepressant medication. We examined the effect of acute (10 weeks), open-label desipramine (DMI) treatment on social functioning in subjects with DSM-III-R dysthymia. Social functioning was assessed with the social adjustment scale self-report (SAS-SR) at baseline and at week 10. Compared with DMI nonresponders, DMI responders showed significantly greater improvement in overall social functioning (F_2,45 = 5.46, P < 0.0001) and in enjoyment of leisure time (F_2,45 = 14.38, P < 0.0001) on the SAS-SR. Dysthymic patients who respond to DMI improve significantly in social functioning. Diminished capacity to enjoy leisure time may be a state marker of depression in some chronically depressed patients.

Original language	English (US)
Pages (from-to)	85-88
Number of pages	4
Journal	Journal of Affective Disorders
Volume	34
Issue number	2
DOIs	https://doi.org/10.1016/0165-0327(95)00003-6
State	Published - May 17 1995
Externally published	Yes

Keywords

Desipramine
Dysthymia
Social functioning

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

Access to Document

10.1016/0165-0327(95)00003-6

Fingerprint Dive into the research topics of 'Acute response of social functioning in dysthymic patients with desipramine'. Together they form a unique fingerprint.

Cite this

@article{f8b3ae5386c44c2089e1b7e90ef06bf7,

title = "Acute response of social functioning in dysthymic patients with desipramine",

abstract = "Despite some evidence that short-term antidepressant treatment improves social dysfunction in depressed patients, little is known about the response of specific social impairments in dysthymic patients to antidepressant medication. We examined the effect of acute (10 weeks), open-label desipramine (DMI) treatment on social functioning in subjects with DSM-III-R dysthymia. Social functioning was assessed with the social adjustment scale self-report (SAS-SR) at baseline and at week 10. Compared with DMI nonresponders, DMI responders showed significantly greater improvement in overall social functioning (F2,45 = 5.46, P < 0.0001) and in enjoyment of leisure time (F2,45 = 14.38, P < 0.0001) on the SAS-SR. Dysthymic patients who respond to DMI improve significantly in social functioning. Diminished capacity to enjoy leisure time may be a state marker of depression in some chronically depressed patients.",

keywords = "Desipramine, Dysthymia, Social functioning",

author = "Friedman, {Richard A.} and Markowitz, {John C.} and Michael Parides and Kocsis, {James H.}",

year = "1995",

month = may,

day = "17",

doi = "10.1016/0165-0327(95)00003-6",

language = "English (US)",

volume = "34",

pages = "85--88",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Acute response of social functioning in dysthymic patients with desipramine

AU - Friedman, Richard A.

AU - Markowitz, John C.

AU - Parides, Michael

AU - Kocsis, James H.

PY - 1995/5/17

Y1 - 1995/5/17

N2 - Despite some evidence that short-term antidepressant treatment improves social dysfunction in depressed patients, little is known about the response of specific social impairments in dysthymic patients to antidepressant medication. We examined the effect of acute (10 weeks), open-label desipramine (DMI) treatment on social functioning in subjects with DSM-III-R dysthymia. Social functioning was assessed with the social adjustment scale self-report (SAS-SR) at baseline and at week 10. Compared with DMI nonresponders, DMI responders showed significantly greater improvement in overall social functioning (F2,45 = 5.46, P < 0.0001) and in enjoyment of leisure time (F2,45 = 14.38, P < 0.0001) on the SAS-SR. Dysthymic patients who respond to DMI improve significantly in social functioning. Diminished capacity to enjoy leisure time may be a state marker of depression in some chronically depressed patients.

AB - Despite some evidence that short-term antidepressant treatment improves social dysfunction in depressed patients, little is known about the response of specific social impairments in dysthymic patients to antidepressant medication. We examined the effect of acute (10 weeks), open-label desipramine (DMI) treatment on social functioning in subjects with DSM-III-R dysthymia. Social functioning was assessed with the social adjustment scale self-report (SAS-SR) at baseline and at week 10. Compared with DMI nonresponders, DMI responders showed significantly greater improvement in overall social functioning (F2,45 = 5.46, P < 0.0001) and in enjoyment of leisure time (F2,45 = 14.38, P < 0.0001) on the SAS-SR. Dysthymic patients who respond to DMI improve significantly in social functioning. Diminished capacity to enjoy leisure time may be a state marker of depression in some chronically depressed patients.

KW - Desipramine

KW - Dysthymia

KW - Social functioning

UR - http://www.scopus.com/inward/record.url?scp=0029072136&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029072136&partnerID=8YFLogxK

U2 - 10.1016/0165-0327(95)00003-6

DO - 10.1016/0165-0327(95)00003-6

M3 - Article

C2 - 7665809

AN - SCOPUS:0029072136

VL - 34

SP - 85

EP - 88

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 2

ER -