Acute megakaryoblastic leukemia mimicking small round cell tumor with novel t(1;5)(q21;p13)

Suheyla Uyar Bozkurt, Su Gulsun Berrak, Halil Tugtepe, Cengiz Canpolat, Sukru Palanduz, Tulay Tecimer

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Acute megakaryoblastic leukemia is a relatively rare form of acute leukemia that has heterogeneous blast morphology and karyotypic abnormalities. An 8-month-old boy with a retroperitoneal mass was diagnosed as having acute megakaryoblastic leukemia that initially presented as small round cell tumor of childhood. Bone marrow aspiration showed syncytial groups of atypical medium sized cells with scant cytoplasm and fine nuclear chromatin. Retroperitoneal mass biopsy showed several lymph nodes with cohesive clusters of neoplastic cells that demonstrated expression of Factor VIII. Flow cytometric analysis of the second bone marrow aspiration showed CD 61 positivity. Karyotypic analysis of bone marrow cells showed a novel translocation, (1;5)(q21;p13).

Original languageEnglish (US)
Pages (from-to)163-166
Number of pages4
JournalAPMIS
Volume116
Issue number2
DOIs
StatePublished - Feb 2008
Externally publishedYes

Fingerprint

Leukemia, Megakaryoblastic, Acute
Bone Marrow
Neoplasms
Factor VIII
Bone Marrow Cells
Chromatin
Cytoplasm
Leukemia
Lymph Nodes
Biopsy

Keywords

  • Acute megakaryoblastic leukemia
  • Cytogenetics
  • Metastatic carcinoma
  • Small round cell tumor
  • t(1;5)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Microbiology (medical)
  • Immunology

Cite this

Bozkurt, S. U., Berrak, S. G., Tugtepe, H., Canpolat, C., Palanduz, S., & Tecimer, T. (2008). Acute megakaryoblastic leukemia mimicking small round cell tumor with novel t(1;5)(q21;p13). APMIS, 116(2), 163-166. https://doi.org/10.1111/j.1600-0463.2008.00780.x

Acute megakaryoblastic leukemia mimicking small round cell tumor with novel t(1;5)(q21;p13). / Bozkurt, Suheyla Uyar; Berrak, Su Gulsun; Tugtepe, Halil; Canpolat, Cengiz; Palanduz, Sukru; Tecimer, Tulay.

In: APMIS, Vol. 116, No. 2, 02.2008, p. 163-166.

Research output: Contribution to journalArticle

Bozkurt, SU, Berrak, SG, Tugtepe, H, Canpolat, C, Palanduz, S & Tecimer, T 2008, 'Acute megakaryoblastic leukemia mimicking small round cell tumor with novel t(1;5)(q21;p13)', APMIS, vol. 116, no. 2, pp. 163-166. https://doi.org/10.1111/j.1600-0463.2008.00780.x
Bozkurt SU, Berrak SG, Tugtepe H, Canpolat C, Palanduz S, Tecimer T. Acute megakaryoblastic leukemia mimicking small round cell tumor with novel t(1;5)(q21;p13). APMIS. 2008 Feb;116(2):163-166. https://doi.org/10.1111/j.1600-0463.2008.00780.x
Bozkurt, Suheyla Uyar ; Berrak, Su Gulsun ; Tugtepe, Halil ; Canpolat, Cengiz ; Palanduz, Sukru ; Tecimer, Tulay. / Acute megakaryoblastic leukemia mimicking small round cell tumor with novel t(1;5)(q21;p13). In: APMIS. 2008 ; Vol. 116, No. 2. pp. 163-166.
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