Acute leukemia with t(10;11)(p11-p15;q13-q23)

Christiane Secco, Peter H. Wiernik, John M. Bennett, Elisabeth M. Paietta

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We report six patients with acute leukemia characterized by the presence of a t(10;11) (p11-p15;q13-q23), either as sole cytogenetic abnormality (three patients) or as part of a complex abnormal karyotype. The morphologic and cytochemical features of four patients were consistent with FAB-M5A, while two patients presented with FAB-L1 characteristics. By immunophenotyping, myeloid leukemia was diagnosed in five patients, including one patient with FAB-L1 leukemia who typed as terminal transferase (TdT)+, CD7 T-cell antigen+ acute myelomonocytic leukemia. Differentiated acute myeloid leukemia (AML) with expression of terminal transferase was found in two of the other cases and monocytic leukemia in two, with co-expression of T-cell antigens in one of them. The second FAB-L1 patient typed as undifferentiated acute lymphocytic leukemia (ALL) expressing myeloid antigens. Serial phenotypic studies in patient 3 during the course of the disease demonstrated a switch from monocytic to lymphoid morphology at the time of first and second relapse, which was paralleled by the appearance of a pre-T ALL immunophenotype with co-expression of the myeloid antigen CD33. These phenotypic changes occurred without apparent alteration in the genotype since t(10;11)(p11.2;q23) remained the only cytogenetic aberration at all stages of the disease. Our observations suggest that the (10;11) variant of 11q aberrations occurs in a bipotential myelomonocytic/T-lymphoid stem cell.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume86
Issue number1
DOIs
StatePublished - Jan 1996

Fingerprint

Leukemia
Viral Tumor Antigens
Transferases
Chromosome Aberrations
CD7 Antigens
Sialic Acid Binding Ig-like Lectin 3
Lymphoid Progenitor Cells
Leukemia, Myelomonocytic, Acute
Abnormal Karyotype
T-Lymphocytes
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Immunophenotyping
Myeloid Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Genotype
Antigens
Recurrence

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Acute leukemia with t(10;11)(p11-p15;q13-q23). / Secco, Christiane; Wiernik, Peter H.; Bennett, John M.; Paietta, Elisabeth M.

In: Cancer Genetics and Cytogenetics, Vol. 86, No. 1, 01.1996, p. 31-34.

Research output: Contribution to journalArticle

Secco, Christiane ; Wiernik, Peter H. ; Bennett, John M. ; Paietta, Elisabeth M. / Acute leukemia with t(10;11)(p11-p15;q13-q23). In: Cancer Genetics and Cytogenetics. 1996 ; Vol. 86, No. 1. pp. 31-34.
@article{1cb2525236074686812ae23458b93fa1,
title = "Acute leukemia with t(10;11)(p11-p15;q13-q23)",
abstract = "We report six patients with acute leukemia characterized by the presence of a t(10;11) (p11-p15;q13-q23), either as sole cytogenetic abnormality (three patients) or as part of a complex abnormal karyotype. The morphologic and cytochemical features of four patients were consistent with FAB-M5A, while two patients presented with FAB-L1 characteristics. By immunophenotyping, myeloid leukemia was diagnosed in five patients, including one patient with FAB-L1 leukemia who typed as terminal transferase (TdT)+, CD7 T-cell antigen+ acute myelomonocytic leukemia. Differentiated acute myeloid leukemia (AML) with expression of terminal transferase was found in two of the other cases and monocytic leukemia in two, with co-expression of T-cell antigens in one of them. The second FAB-L1 patient typed as undifferentiated acute lymphocytic leukemia (ALL) expressing myeloid antigens. Serial phenotypic studies in patient 3 during the course of the disease demonstrated a switch from monocytic to lymphoid morphology at the time of first and second relapse, which was paralleled by the appearance of a pre-T ALL immunophenotype with co-expression of the myeloid antigen CD33. These phenotypic changes occurred without apparent alteration in the genotype since t(10;11)(p11.2;q23) remained the only cytogenetic aberration at all stages of the disease. Our observations suggest that the (10;11) variant of 11q aberrations occurs in a bipotential myelomonocytic/T-lymphoid stem cell.",
author = "Christiane Secco and Wiernik, {Peter H.} and Bennett, {John M.} and Paietta, {Elisabeth M.}",
year = "1996",
month = "1",
doi = "10.1016/0165-4608(95)00165-4",
language = "English (US)",
volume = "86",
pages = "31--34",
journal = "Cancer Genetics and Cytogenetics",
issn = "0165-4608",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Acute leukemia with t(10;11)(p11-p15;q13-q23)

AU - Secco, Christiane

AU - Wiernik, Peter H.

AU - Bennett, John M.

AU - Paietta, Elisabeth M.

PY - 1996/1

Y1 - 1996/1

N2 - We report six patients with acute leukemia characterized by the presence of a t(10;11) (p11-p15;q13-q23), either as sole cytogenetic abnormality (three patients) or as part of a complex abnormal karyotype. The morphologic and cytochemical features of four patients were consistent with FAB-M5A, while two patients presented with FAB-L1 characteristics. By immunophenotyping, myeloid leukemia was diagnosed in five patients, including one patient with FAB-L1 leukemia who typed as terminal transferase (TdT)+, CD7 T-cell antigen+ acute myelomonocytic leukemia. Differentiated acute myeloid leukemia (AML) with expression of terminal transferase was found in two of the other cases and monocytic leukemia in two, with co-expression of T-cell antigens in one of them. The second FAB-L1 patient typed as undifferentiated acute lymphocytic leukemia (ALL) expressing myeloid antigens. Serial phenotypic studies in patient 3 during the course of the disease demonstrated a switch from monocytic to lymphoid morphology at the time of first and second relapse, which was paralleled by the appearance of a pre-T ALL immunophenotype with co-expression of the myeloid antigen CD33. These phenotypic changes occurred without apparent alteration in the genotype since t(10;11)(p11.2;q23) remained the only cytogenetic aberration at all stages of the disease. Our observations suggest that the (10;11) variant of 11q aberrations occurs in a bipotential myelomonocytic/T-lymphoid stem cell.

AB - We report six patients with acute leukemia characterized by the presence of a t(10;11) (p11-p15;q13-q23), either as sole cytogenetic abnormality (three patients) or as part of a complex abnormal karyotype. The morphologic and cytochemical features of four patients were consistent with FAB-M5A, while two patients presented with FAB-L1 characteristics. By immunophenotyping, myeloid leukemia was diagnosed in five patients, including one patient with FAB-L1 leukemia who typed as terminal transferase (TdT)+, CD7 T-cell antigen+ acute myelomonocytic leukemia. Differentiated acute myeloid leukemia (AML) with expression of terminal transferase was found in two of the other cases and monocytic leukemia in two, with co-expression of T-cell antigens in one of them. The second FAB-L1 patient typed as undifferentiated acute lymphocytic leukemia (ALL) expressing myeloid antigens. Serial phenotypic studies in patient 3 during the course of the disease demonstrated a switch from monocytic to lymphoid morphology at the time of first and second relapse, which was paralleled by the appearance of a pre-T ALL immunophenotype with co-expression of the myeloid antigen CD33. These phenotypic changes occurred without apparent alteration in the genotype since t(10;11)(p11.2;q23) remained the only cytogenetic aberration at all stages of the disease. Our observations suggest that the (10;11) variant of 11q aberrations occurs in a bipotential myelomonocytic/T-lymphoid stem cell.

UR - http://www.scopus.com/inward/record.url?scp=0029883768&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029883768&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(95)00165-4

DO - 10.1016/0165-4608(95)00165-4

M3 - Article

C2 - 8616782

AN - SCOPUS:0029883768

VL - 86

SP - 31

EP - 34

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

SN - 0165-4608

IS - 1

ER -