Acute footshock-stress increases spatial learning-memory and correlates to increased hippocampal BDNF and VEGF and cell numbers in adolescent male and female rats

Nazan Uysal, Ali Riza Sisman, Ayfer Dayi, Seda Ozbal, Ferihan Cetin, Basak Baykara, Ilkay Aksu, Aysegul Tas, Secil Ayca Cavus, Sevil Gonenc-Arda, Erkan Buyuk

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

It is well known that the acute-stress enhances cognitive functions in adults, but is not known in adolescents. The purpose of this study is to investigate the effects of low and high intensities of acute-stress on hippocampus and spatial memory in the adolescent male and female rats. Thirty-eight days aged rats were subjected to 0.2 and 1.6. mA intensity of footshock-stress for 20. min. Spatial memory performance was assessed in the Morris water maze. Learning had been positively affected in stress groups. Neuron density in the CA1 hippocampal region and the gyrus dentatus as well as VEGF and BDNF levels of hippocampus increased in all stress groups. In females, learning process and BDNF levels increased in low-intensity-stress group than high-intensity-stress group. There was no difference in hippocampal apoptosis among groups.We conclude that adolescent hippocampus is affected positively from acute-stress; however, while there is no difference in male response with respect to intensity of stress, females are affected more positively from low-intensity of stress.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalNeuroscience Letters
Volume514
Issue number2
DOIs
StatePublished - Apr 18 2012

Keywords

  • Acute-stress
  • Adolescent
  • BDNF
  • Footshock
  • Hippocampus
  • Learning and memory
  • VEGF

ASJC Scopus subject areas

  • Neuroscience(all)

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    Uysal, N., Sisman, A. R., Dayi, A., Ozbal, S., Cetin, F., Baykara, B., Aksu, I., Tas, A., Cavus, S. A., Gonenc-Arda, S., & Buyuk, E. (2012). Acute footshock-stress increases spatial learning-memory and correlates to increased hippocampal BDNF and VEGF and cell numbers in adolescent male and female rats. Neuroscience Letters, 514(2), 141-146. https://doi.org/10.1016/j.neulet.2012.02.049