Abstract
Patients with Alzheimer's disease (AD) have a higher risk for developing insulin resistance and diabetes. Amyloid plaques, a hallmark of AD, are composed of amyloid-β (Aβ). Because the mediobasal hypothalamus controls hepatic glucose production, we examined the hypothesis that its exposure to Aβ perturbs the regulation of glucose metabolism. The infusion of Aβ25-35, but not its scrambled counterpart, into the mediobasal hypothalamus of young rats, increased circulating glucose as a consequence of enhanced hepatic glucose production during pancreatic clamp studies. These findings suggest a link between AD and alterations of glucose metabolism.
Original language | English (US) |
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Pages (from-to) | 843-848 |
Number of pages | 6 |
Journal | Journal of Alzheimer's Disease |
Volume | 46 |
Issue number | 4 |
DOIs | |
State | Published - Jun 26 2015 |
Keywords
- Alzheimer's disease
- amyloid-β
- diabetes
- glucose homeostasis
- hyperglycemia
- mediobasal hypothalamus
ASJC Scopus subject areas
- General Neuroscience
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health