Acute colchicine intoxication - Possible role of erythromycin administration

Y. Caraco, C. Putterman, R. Rahamimov, E. Ben-Chetrit

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

A 29-year-old patient with familial Mediterranean fever and amyloidosis involving the kidney, liver, and gastrointestinal tract received longterm colchicine, 1 mg daily. In the last year she developed diarrhea and abdominal pain, that coincided with toxic colchicine blood levels. After 2 weeks of oral erythromycin therapy she was hospitalized for acute, life threatening colchicine toxicity, with fever, diarrhea, abdominal pain, myalgia and lower extremity parasthesias and later convulsions and alopecia. Pancytopenia evolved into rebound leukocytosis, disturbed liver function and hypoglycemia. After a long stormy course she improved. Colchicine toxicity with combined liver and renal impairment and the role of erythromycin in her colchicine toxicity are discussed.

Original languageEnglish (US)
Pages (from-to)494-496
Number of pages3
JournalJournal of Rheumatology
Volume19
Issue number3
StatePublished - 1992
Externally publishedYes

Keywords

  • FMF
  • amyloidosis
  • colchicine toxicity
  • erythromycin

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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    Caraco, Y., Putterman, C., Rahamimov, R., & Ben-Chetrit, E. (1992). Acute colchicine intoxication - Possible role of erythromycin administration. Journal of Rheumatology, 19(3), 494-496.