Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease: A randomized double-blind placebo-controlled study

H. M Omar Farouque, Michael Leung, Sarah A. Hope, Mauro Baldi, Clyde B. Schechter, James D. Cameron, Ian T. Meredith

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Evidence suggests that flavonoid-containing diets reduce cardiovascular risk, but the mechanisms responsible are unclear. In the present study, we sought to determine the effect of flavanol-rich cocoa on vascular function in individuals with CAD (coronary artery disease). Forty subjects (61+8 years; 30 male) with CAD were recruited to a 6-week randomized double-blind placebo-controlled study. Subjects consumed either a flavanol-rich chocolate bar and cocoa beverage daily (total flavanols, 444 mg/day) or matching isocaloric placebos daily (total flavanols, 19.6 mg/day) for 6 weeks. Brachial artery FMD (flow-mediated dilation) and SAC (systemic arterial compliance) were assessed at baseline, 90 min following the first beverage and after 3 and 6 weeks of daily consumption. Soluble cellular adhesion molecules and FBF (forearm blood flow) responses to ACh (acetylcholine chloride; 3-30 μg/min) and SNP (sodium nitroprusside; 0.3-3 μg/min) infusions, forearm ischaemia and isotonic forearm exercise were assessed at baseline and after 6 weeks. FMD, SAC and FBF responses did not differ between groups at baseline. No acute or chronic changes in FMD or SAC were seen in either group. No difference in soluble cellular adhesion molecules, FBF responses to ischaemia, exercise, SNP or ACh was seen in the group receiving flavanol-rich cocoa between baseline and 6 weeks. These data suggest that over a 6-week period, flavanol-rich cocoa does not modify vascular function in patients with established CAD.

Original languageEnglish (US)
Pages (from-to)71-80
Number of pages10
JournalClinical Science
Volume111
Issue number1
DOIs
StatePublished - Jul 2006

Fingerprint

Forearm
Blood Vessels
Coronary Artery Disease
Placebos
Compliance
Dilatation
Beverages
Single Nucleotide Polymorphism
Ischemia
Exercise
Brachial Artery
Nitroprusside
Flavonoids
Acetylcholine
Diet

Keywords

  • Blood flow
  • Coronary disease
  • Diet
  • Endothelium
  • Flavonoid

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease : A randomized double-blind placebo-controlled study. / Farouque, H. M Omar; Leung, Michael; Hope, Sarah A.; Baldi, Mauro; Schechter, Clyde B.; Cameron, James D.; Meredith, Ian T.

In: Clinical Science, Vol. 111, No. 1, 07.2006, p. 71-80.

Research output: Contribution to journalArticle

Farouque, H. M Omar ; Leung, Michael ; Hope, Sarah A. ; Baldi, Mauro ; Schechter, Clyde B. ; Cameron, James D. ; Meredith, Ian T. / Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease : A randomized double-blind placebo-controlled study. In: Clinical Science. 2006 ; Vol. 111, No. 1. pp. 71-80.
@article{fa9a4c2f0f7849c182738e6423a585d3,
title = "Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease: A randomized double-blind placebo-controlled study",
abstract = "Evidence suggests that flavonoid-containing diets reduce cardiovascular risk, but the mechanisms responsible are unclear. In the present study, we sought to determine the effect of flavanol-rich cocoa on vascular function in individuals with CAD (coronary artery disease). Forty subjects (61+8 years; 30 male) with CAD were recruited to a 6-week randomized double-blind placebo-controlled study. Subjects consumed either a flavanol-rich chocolate bar and cocoa beverage daily (total flavanols, 444 mg/day) or matching isocaloric placebos daily (total flavanols, 19.6 mg/day) for 6 weeks. Brachial artery FMD (flow-mediated dilation) and SAC (systemic arterial compliance) were assessed at baseline, 90 min following the first beverage and after 3 and 6 weeks of daily consumption. Soluble cellular adhesion molecules and FBF (forearm blood flow) responses to ACh (acetylcholine chloride; 3-30 μg/min) and SNP (sodium nitroprusside; 0.3-3 μg/min) infusions, forearm ischaemia and isotonic forearm exercise were assessed at baseline and after 6 weeks. FMD, SAC and FBF responses did not differ between groups at baseline. No acute or chronic changes in FMD or SAC were seen in either group. No difference in soluble cellular adhesion molecules, FBF responses to ischaemia, exercise, SNP or ACh was seen in the group receiving flavanol-rich cocoa between baseline and 6 weeks. These data suggest that over a 6-week period, flavanol-rich cocoa does not modify vascular function in patients with established CAD.",
keywords = "Blood flow, Coronary disease, Diet, Endothelium, Flavonoid",
author = "Farouque, {H. M Omar} and Michael Leung and Hope, {Sarah A.} and Mauro Baldi and Schechter, {Clyde B.} and Cameron, {James D.} and Meredith, {Ian T.}",
year = "2006",
month = "7",
doi = "10.1042/CS20060048",
language = "English (US)",
volume = "111",
pages = "71--80",
journal = "Clinical Science",
issn = "0143-5221",
publisher = "Portland Press Ltd.",
number = "1",

}

TY - JOUR

T1 - Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease

T2 - A randomized double-blind placebo-controlled study

AU - Farouque, H. M Omar

AU - Leung, Michael

AU - Hope, Sarah A.

AU - Baldi, Mauro

AU - Schechter, Clyde B.

AU - Cameron, James D.

AU - Meredith, Ian T.

PY - 2006/7

Y1 - 2006/7

N2 - Evidence suggests that flavonoid-containing diets reduce cardiovascular risk, but the mechanisms responsible are unclear. In the present study, we sought to determine the effect of flavanol-rich cocoa on vascular function in individuals with CAD (coronary artery disease). Forty subjects (61+8 years; 30 male) with CAD were recruited to a 6-week randomized double-blind placebo-controlled study. Subjects consumed either a flavanol-rich chocolate bar and cocoa beverage daily (total flavanols, 444 mg/day) or matching isocaloric placebos daily (total flavanols, 19.6 mg/day) for 6 weeks. Brachial artery FMD (flow-mediated dilation) and SAC (systemic arterial compliance) were assessed at baseline, 90 min following the first beverage and after 3 and 6 weeks of daily consumption. Soluble cellular adhesion molecules and FBF (forearm blood flow) responses to ACh (acetylcholine chloride; 3-30 μg/min) and SNP (sodium nitroprusside; 0.3-3 μg/min) infusions, forearm ischaemia and isotonic forearm exercise were assessed at baseline and after 6 weeks. FMD, SAC and FBF responses did not differ between groups at baseline. No acute or chronic changes in FMD or SAC were seen in either group. No difference in soluble cellular adhesion molecules, FBF responses to ischaemia, exercise, SNP or ACh was seen in the group receiving flavanol-rich cocoa between baseline and 6 weeks. These data suggest that over a 6-week period, flavanol-rich cocoa does not modify vascular function in patients with established CAD.

AB - Evidence suggests that flavonoid-containing diets reduce cardiovascular risk, but the mechanisms responsible are unclear. In the present study, we sought to determine the effect of flavanol-rich cocoa on vascular function in individuals with CAD (coronary artery disease). Forty subjects (61+8 years; 30 male) with CAD were recruited to a 6-week randomized double-blind placebo-controlled study. Subjects consumed either a flavanol-rich chocolate bar and cocoa beverage daily (total flavanols, 444 mg/day) or matching isocaloric placebos daily (total flavanols, 19.6 mg/day) for 6 weeks. Brachial artery FMD (flow-mediated dilation) and SAC (systemic arterial compliance) were assessed at baseline, 90 min following the first beverage and after 3 and 6 weeks of daily consumption. Soluble cellular adhesion molecules and FBF (forearm blood flow) responses to ACh (acetylcholine chloride; 3-30 μg/min) and SNP (sodium nitroprusside; 0.3-3 μg/min) infusions, forearm ischaemia and isotonic forearm exercise were assessed at baseline and after 6 weeks. FMD, SAC and FBF responses did not differ between groups at baseline. No acute or chronic changes in FMD or SAC were seen in either group. No difference in soluble cellular adhesion molecules, FBF responses to ischaemia, exercise, SNP or ACh was seen in the group receiving flavanol-rich cocoa between baseline and 6 weeks. These data suggest that over a 6-week period, flavanol-rich cocoa does not modify vascular function in patients with established CAD.

KW - Blood flow

KW - Coronary disease

KW - Diet

KW - Endothelium

KW - Flavonoid

UR - http://www.scopus.com/inward/record.url?scp=33745792387&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745792387&partnerID=8YFLogxK

U2 - 10.1042/CS20060048

DO - 10.1042/CS20060048

M3 - Article

C2 - 16551272

AN - SCOPUS:33745792387

VL - 111

SP - 71

EP - 80

JO - Clinical Science

JF - Clinical Science

SN - 0143-5221

IS - 1

ER -