Activity, mechanism of action and pharmacokinetics of 2-tert-butylbenzothiazole and CGP 6140 (amocarzine) antifilarial drugs

Medicine & Life Sciences

• amocarzine 100%
• Pharmacokinetics 35%
• Thiourea 23%
• isothiocyanic acid 19%
• Parasites 19%
• Pharmaceutical Preparations 19%
• Acetylcholinesterase 17%
• CGP 20376 17%
• amoscanate 16%
• Esters 16%
• Isothiocyanates 12%
• Acids 11%
• Organelles 7%
• Respiration 6%
• Mitochondria 6%
• Psychological Inhibition 6%
• Clinical Trials 5%
• Drug Therapy 4%
• Enzymes 4%
• In Vitro Techniques 3%

Agriculture & Biology

• pharmacokinetics 46%
• mechanism of action 40%
• drugs 31%
• isothiocyanates 27%
• thiourea 20%
• acetylcholinesterase 16%
• parasites 16%
• esters 12%
• onchocerciasis 10%
• acids 8%
• clinical trials 8%
• drug therapy 7%
• aqueous solutions 7%
• linkage (genetics) 7%
• organelles 6%
• breathing 6%
• adverse effects 6%
• chemical derivatives 6%
• mitochondria 6%
• toxicity 5%
• uptake mechanisms 5%
• pathogens 4%
• enzymes 3%
• testing 3%