Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons

Bryen A. Jordan, Brian D. Fernholz, Latika Khatri, Edward B. Ziff

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Neuronal development, plasticity and survival require activity-dependent synapse-to-nucleus signaling. Most studies implicate an activity-dependent regulation of gene expression in this phenomenon. However, little is known about other nuclear functions that are regulated by synaptic activity. Here we show that a newly identified component of rat postsynaptic densities (PSDs), AIDA-1d, can regulate global protein synthesis by altering nucleolar numbers. AIDA-1d binds to the first two postsynaptic density-95/Discs large/zona occludens-1 (PDZ) domains of the scaffolding protein PSD-95 via its C-terminal three amino acids. Stimulation of NMDA receptors (NMDARs), which are also bound to PSD-95, results in a Ca2+-independent translocation of AIDA-1d to the nucleus, where it couples to Cajal bodies and induces Cajal body-nucleolar association. Long-term neuronal stimulation results in an AIDA-1-dependent increase in nucleolar numbers and protein synthesis. We propose that AIDA-1d mediates a link between synaptic activity and control of protein biosynthetic capacity by regulating nucleolar assembly.

Original languageEnglish (US)
Pages (from-to)427-435
Number of pages9
JournalNature Neuroscience
Volume10
Issue number4
DOIs
StatePublished - Apr 2007
Externally publishedYes

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Post-Synaptic Density
Nuclear Proteins
Neurons
PDZ Domains
Neuronal Plasticity
Herpes Zoster
Gene Expression Regulation
N-Methyl-D-Aspartate Receptors
Recombinant Proteins
Synapses
Amino Acids
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons. / Jordan, Bryen A.; Fernholz, Brian D.; Khatri, Latika; Ziff, Edward B.

In: Nature Neuroscience, Vol. 10, No. 4, 04.2007, p. 427-435.

Research output: Contribution to journalArticle

Jordan, Bryen A. ; Fernholz, Brian D. ; Khatri, Latika ; Ziff, Edward B. / Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons. In: Nature Neuroscience. 2007 ; Vol. 10, No. 4. pp. 427-435.
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