Activation of human macrophages. Comparison of other cytokines with interferon-γ

C. F. Nathan, T. J. Prendergast, M. E. Wiebe, E. R. Stanley, E. Platzer, H. G. Remold, K. Welte, B. Y. Rubin, H. W. Murray

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Abstract

Cytokines affecting mononuclear phagocytes were screened for activation of human macrophages to secrete H2O2 and kill toxoplasmas. In contrast to recombinant interferon-γ (rIFNγ), the following factors, tested in partially or highly purified form and over a wide range of concentrations, did not augment these functions: native interferon-α (nIFNα), rIFNαA, rIFNαD, rIFNβ, colony stimulating factor (type 1) (CSF-1), CSF for granulocytes and macrophages (GM-CSF), pluripotent CSF (p-CSF), tumor necrosis factor (TNF), native interleukin 2 (nIL-2), and rIL-2. Partially purified migration inhibitory factor (MIF) enhanced H2O2-releasing capacity submaximally without inducing antitoxoplasma activity, and warrants further study.

Original languageEnglish (US)
Pages (from-to)600-605
Number of pages6
JournalJournal of Experimental Medicine
Volume160
Issue number2
StatePublished - 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

Cite this

Nathan, C. F., Prendergast, T. J., Wiebe, M. E., Stanley, E. R., Platzer, E., Remold, H. G., Welte, K., Rubin, B. Y., & Murray, H. W. (1984). Activation of human macrophages. Comparison of other cytokines with interferon-γ. Journal of Experimental Medicine, 160(2), 600-605.