TY - JOUR
T1 - Activation of human macrophages
T2 - Comparison of other cytokines with interferon-γ
AU - Nathan, Carl F.
AU - Prendergast, Thomas J.
AU - Wiebe, Michael E.
AU - Richard Stanley, E.
AU - Platzer, Erich
AU - Remold, Heinz G.
AU - Welte, Karl
AU - Rubin, Berish Y.
AU - Murray, Henry W.
PY - 1984/8/1
Y1 - 1984/8/1
N2 - Cytokines affecting mononuclear phagocytes were screened for activation of human macrophages to secrete H2O2 and kill toxoplasmas. In contrast to recombinant interferon-γ (rIFNγ), the following factors, tested in partially or highly purified form and over a wide range of concentrations, did not augment these functions: native interferon-α (nIFNα), rIFNαA, rIFNαD, rIFNβ, colony stimulating factor (type 1) (CSF-1), CSF for granulocytes and macrophages (GM-CSF), pluripotent CSF (p-CSF), tumor necrosis factor (TNF), native interleukin 2 (nIL-2), and rIL-2. Partially purified migration inhibitory factor (MIF) enhanced H2O2-releasing capacity submaximally without inducing antitoxoplasma activity, and warrants further study.
AB - Cytokines affecting mononuclear phagocytes were screened for activation of human macrophages to secrete H2O2 and kill toxoplasmas. In contrast to recombinant interferon-γ (rIFNγ), the following factors, tested in partially or highly purified form and over a wide range of concentrations, did not augment these functions: native interferon-α (nIFNα), rIFNαA, rIFNαD, rIFNβ, colony stimulating factor (type 1) (CSF-1), CSF for granulocytes and macrophages (GM-CSF), pluripotent CSF (p-CSF), tumor necrosis factor (TNF), native interleukin 2 (nIL-2), and rIL-2. Partially purified migration inhibitory factor (MIF) enhanced H2O2-releasing capacity submaximally without inducing antitoxoplasma activity, and warrants further study.
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U2 - 10.1084/jem.160.2.600
DO - 10.1084/jem.160.2.600
M3 - Article
C2 - 6206183
AN - SCOPUS:0021209709
SN - 0022-1007
VL - 160
SP - 600
EP - 605
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 2
ER -