Activation of blood clotting in patients with systemic lupus erythematosus. Relationship to disease activity

John A. Hardin, Malcolm Cronlund, Edgar Haber, Kurt J. Bloch

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

We used a radioimmunoassay for fibrinopeptide A (FPA) to detect activation of blood clotting in patients with systemic lupus erythematosus (SLE). FPA levels were elevated in all patients with any degree of clinically detectable inflammation but were normal (< 1.5 ng/ml) or near normal in most patients in remission. The increase in concentration of plasma FPA varied directly with the number of organ systems that showed evidence of inflammation. In individual patients, changes in FPA preceded or closely paralleled changes in disease activity. We observed marked increases in FPA concentration prior to clinical exacerbations and marked decreases prior to drug-induced remissions. The activity of the clotting system as reflected by plasma FPA values appears to parallel the extent of inflammation and to provide a sensitive index of disease activity in patients with SLE.

Original languageEnglish (US)
Pages (from-to)430-436
Number of pages7
JournalThe American journal of medicine
Volume65
Issue number3
DOIs
StatePublished - 1978

Fingerprint

Fibrinopeptide A
Blood Coagulation
Systemic Lupus Erythematosus
Inflammation
Radioimmunoassay
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Activation of blood clotting in patients with systemic lupus erythematosus. Relationship to disease activity. / Hardin, John A.; Cronlund, Malcolm; Haber, Edgar; Bloch, Kurt J.

In: The American journal of medicine, Vol. 65, No. 3, 1978, p. 430-436.

Research output: Contribution to journalArticle

Hardin, John A. ; Cronlund, Malcolm ; Haber, Edgar ; Bloch, Kurt J. / Activation of blood clotting in patients with systemic lupus erythematosus. Relationship to disease activity. In: The American journal of medicine. 1978 ; Vol. 65, No. 3. pp. 430-436.
@article{57de32d8958d450ba473bff5a9826a01,
title = "Activation of blood clotting in patients with systemic lupus erythematosus. Relationship to disease activity",
abstract = "We used a radioimmunoassay for fibrinopeptide A (FPA) to detect activation of blood clotting in patients with systemic lupus erythematosus (SLE). FPA levels were elevated in all patients with any degree of clinically detectable inflammation but were normal (< 1.5 ng/ml) or near normal in most patients in remission. The increase in concentration of plasma FPA varied directly with the number of organ systems that showed evidence of inflammation. In individual patients, changes in FPA preceded or closely paralleled changes in disease activity. We observed marked increases in FPA concentration prior to clinical exacerbations and marked decreases prior to drug-induced remissions. The activity of the clotting system as reflected by plasma FPA values appears to parallel the extent of inflammation and to provide a sensitive index of disease activity in patients with SLE.",
author = "Hardin, {John A.} and Malcolm Cronlund and Edgar Haber and Bloch, {Kurt J.}",
year = "1978",
doi = "10.1016/0002-9343(78)90769-6",
language = "English (US)",
volume = "65",
pages = "430--436",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Activation of blood clotting in patients with systemic lupus erythematosus. Relationship to disease activity

AU - Hardin, John A.

AU - Cronlund, Malcolm

AU - Haber, Edgar

AU - Bloch, Kurt J.

PY - 1978

Y1 - 1978

N2 - We used a radioimmunoassay for fibrinopeptide A (FPA) to detect activation of blood clotting in patients with systemic lupus erythematosus (SLE). FPA levels were elevated in all patients with any degree of clinically detectable inflammation but were normal (< 1.5 ng/ml) or near normal in most patients in remission. The increase in concentration of plasma FPA varied directly with the number of organ systems that showed evidence of inflammation. In individual patients, changes in FPA preceded or closely paralleled changes in disease activity. We observed marked increases in FPA concentration prior to clinical exacerbations and marked decreases prior to drug-induced remissions. The activity of the clotting system as reflected by plasma FPA values appears to parallel the extent of inflammation and to provide a sensitive index of disease activity in patients with SLE.

AB - We used a radioimmunoassay for fibrinopeptide A (FPA) to detect activation of blood clotting in patients with systemic lupus erythematosus (SLE). FPA levels were elevated in all patients with any degree of clinically detectable inflammation but were normal (< 1.5 ng/ml) or near normal in most patients in remission. The increase in concentration of plasma FPA varied directly with the number of organ systems that showed evidence of inflammation. In individual patients, changes in FPA preceded or closely paralleled changes in disease activity. We observed marked increases in FPA concentration prior to clinical exacerbations and marked decreases prior to drug-induced remissions. The activity of the clotting system as reflected by plasma FPA values appears to parallel the extent of inflammation and to provide a sensitive index of disease activity in patients with SLE.

UR - http://www.scopus.com/inward/record.url?scp=0017863782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017863782&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(78)90769-6

DO - 10.1016/0002-9343(78)90769-6

M3 - Article

VL - 65

SP - 430

EP - 436

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 3

ER -