Actin is oxidized during myocardial ischemia

Saul R. Powell, Ellen M. Gurzenda, Sayed Emal Wahezi

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Exposure of isolated rat hearts to 30 min global ischemia followed by 60 min reperfusion resulted in a significant 80% increase (p <. 05) in actin content of carbonyl groups, which was associated with significant depression (p <. 05) of postischemic contractile function. This result supports the hypothesis that one mechanism of postischemic contractile dysfunction may be oxidation of contractile proteins.

Original languageEnglish (US)
Pages (from-to)1171-1176
Number of pages6
JournalFree Radical Biology and Medicine
Volume30
Issue number10
DOIs
StatePublished - May 15 2001
Externally publishedYes

Keywords

  • Actin
  • Free radicals
  • Myocardial ischemia
  • Protein carbonyls
  • Protein oxidation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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