Abstract
Exposure of isolated rat hearts to 30 min global ischemia followed by 60 min reperfusion resulted in a significant 80% increase (p <. 05) in actin content of carbonyl groups, which was associated with significant depression (p <. 05) of postischemic contractile function. This result supports the hypothesis that one mechanism of postischemic contractile dysfunction may be oxidation of contractile proteins.
Original language | English (US) |
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Pages (from-to) | 1171-1176 |
Number of pages | 6 |
Journal | Free Radical Biology and Medicine |
Volume | 30 |
Issue number | 10 |
DOIs | |
State | Published - May 15 2001 |
Externally published | Yes |
Keywords
- Actin
- Free radicals
- Myocardial ischemia
- Protein carbonyls
- Protein oxidation
ASJC Scopus subject areas
- Biochemistry
- Physiology (medical)