Actin is oxidized during myocardial ischemia

Saul R. Powell, Ellen M. Gurzenda, Sayed E. Wahezi

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Exposure of isolated rat hearts to 30 min global ischemia followed by 60 min reperfusion resulted in a significant 80% increase (p < .05) in actin content of carbonyl groups, which was associated with significant depression (p < .05) of postischemic contractile function. This result supports the hypothesis that one mechanism of postischemic contractile dysfunction may be oxidation of contractile proteins.

Original languageEnglish (US)
Pages (from-to)1171-1176
Number of pages6
JournalFree Radical Biology and Medicine
Volume30
Issue number10
DOIs
StatePublished - May 15 2001
Externally publishedYes

Fingerprint

Contractile Proteins
Reperfusion
Myocardial Ischemia
Rats
Actins
Ischemia
Oxidation

Keywords

  • Actin
  • Free radicals
  • Myocardial ischemia
  • Protein carbonyls
  • Protein oxidation

ASJC Scopus subject areas

  • Medicine(all)
  • Toxicology
  • Clinical Biochemistry

Cite this

Actin is oxidized during myocardial ischemia. / Powell, Saul R.; Gurzenda, Ellen M.; Wahezi, Sayed E.

In: Free Radical Biology and Medicine, Vol. 30, No. 10, 15.05.2001, p. 1171-1176.

Research output: Contribution to journalArticle

Powell, Saul R. ; Gurzenda, Ellen M. ; Wahezi, Sayed E. / Actin is oxidized during myocardial ischemia. In: Free Radical Biology and Medicine. 2001 ; Vol. 30, No. 10. pp. 1171-1176.
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