Abstract
The elongation factor 1a (EF-1a) of Dictyostelium discoideum is an actin crosslinking protein that gives rise to a unique kind of actin bundle. Purified actin and EF-1a were allowed to form bundles and then were characterized by electron microscopy, computed diffraction analysis, and modeling. In these bundles crosslinked actin filaments are rotated by 90° relative to each other, whereas other known crosslinking proteins require filaments to be unrotated. Bundles of actin EF-1a would tend to exclude other actin bundling proteins. EF-1a can thus regulate the state of the actin cytoskeleton as well as regulate protein synthesis.
Original language | English (US) |
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Pages (from-to) | 248-254 |
Number of pages | 7 |
Journal | Journal of Structural Biology |
Volume | 109 |
Issue number | 3 |
DOIs | |
State | Published - 1992 |
ASJC Scopus subject areas
- Structural Biology