Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos

Christian Agudelo; Wassim Tarraf; Benson Wu; Douglas M. Wallace; Sanjay R. Patel; Susan Redline; Sonya Kaur; Martha Daviglus; Phyllis C. Zee; Guido Simonelli; Yasmin Mossavar-Rahmani; Daniela Sotres-Alvarez; Donglin Zeng; Linda C. Gallo; Hector M. González; Alberto R. Ramos

doi:10.1002/alz.12250

Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos

Christian Agudelo, Wassim Tarraf, Benson Wu, Douglas M. Wallace, Sanjay R. Patel, Susan Redline, Sonya Kaur, Martha Daviglus, Phyllis C. Zee, Guido Simonelli, Yasmin Mossavar-Rahmani, Daniela Sotres-Alvarez, Donglin Zeng, Linda C. Gallo, Hector M. González, Alberto R. Ramos

Epidemiology & Population Health

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Introduction: We determined if actigraphy-derived sleep patterns led to 7-year cognitive decline in middle-aged to older Hispanic/Latino adults. Methods: We examined 1035 adults, 45 to 64 years of age, from the Hispanic Community Health Study/Study of Latinos. Participants had repeated measures of cognitive function 7 years apart, home sleep apnea studies, and 1 week of actigraphy. Survey linear regression evaluated prospective associations between sleep and cognitive change, adjusting for main covariates. Results: Longer sleep-onset latency was associated with declines in global cognitive function, verbal learning, and verbal memory. Longer sleep-onset latency was also cross-sectionally associated with verbal learning, verbal memory, and word fluency. Sleep fragmentation was not associated with cognitive change. Conclusion: In a cohort of mostly middle-aged Hispanic/Latinos, actigraphy-derived sleep-onset latency predicted 7-year cognitive change. These findings may serve as targets for sleep interventions of cognitive decline.

Original language	English (US)
Pages (from-to)	959-968
Number of pages	10
Journal	Alzheimer's and Dementia
Volume	17
Issue number	6
DOIs	https://doi.org/10.1002/alz.12250
State	Published - Jun 2021

Keywords

Hispanic/Latinos
actigraphy
cognitive decline
cohort studies
risk factors in epidemiology
sleep

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience
Health Policy
Developmental Neuroscience
Epidemiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/alz.12250

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Agudelo, C., Tarraf, W., Wu, B., Wallace, D. M., Patel, S. R., Redline, S., Kaur, S., Daviglus, M., Zee, P. C., Simonelli, G., Mossavar-Rahmani, Y., Sotres-Alvarez, D., Zeng, D., Gallo, L. C., González, H. M., & Ramos, A. R. (2021). Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos. Alzheimer's and Dementia, 17(6), 959-968. https://doi.org/10.1002/alz.12250

Agudelo, C, Tarraf, W, Wu, B, Wallace, DM, Patel, SR, Redline, S, Kaur, S, Daviglus, M, Zee, PC, Simonelli, G, Mossavar-Rahmani, Y, Sotres-Alvarez, D, Zeng, D, Gallo, LC, González, HM & Ramos, AR 2021, 'Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos', Alzheimer's and Dementia, vol. 17, no. 6, pp. 959-968. https://doi.org/10.1002/alz.12250

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title = "Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos",

abstract = "Introduction: We determined if actigraphy-derived sleep patterns led to 7-year cognitive decline in middle-aged to older Hispanic/Latino adults. Methods: We examined 1035 adults, 45 to 64 years of age, from the Hispanic Community Health Study/Study of Latinos. Participants had repeated measures of cognitive function 7 years apart, home sleep apnea studies, and 1 week of actigraphy. Survey linear regression evaluated prospective associations between sleep and cognitive change, adjusting for main covariates. Results: Longer sleep-onset latency was associated with declines in global cognitive function, verbal learning, and verbal memory. Longer sleep-onset latency was also cross-sectionally associated with verbal learning, verbal memory, and word fluency. Sleep fragmentation was not associated with cognitive change. Conclusion: In a cohort of mostly middle-aged Hispanic/Latinos, actigraphy-derived sleep-onset latency predicted 7-year cognitive change. These findings may serve as targets for sleep interventions of cognitive decline.",

keywords = "Hispanic/Latinos, actigraphy, cognitive decline, cohort studies, risk factors in epidemiology, sleep",

author = "Christian Agudelo and Wassim Tarraf and Benson Wu and Wallace, {Douglas M.} and Patel, {Sanjay R.} and Susan Redline and Sonya Kaur and Martha Daviglus and Zee, {Phyllis C.} and Guido Simonelli and Yasmin Mossavar-Rahmani and Daniela Sotres-Alvarez and Donglin Zeng and Gallo, {Linda C.} and Gonz{\'a}lez, {Hector M.} and Ramos, {Alberto R.}",

note = "Publisher Copyright: {\textcopyright} 2020 the Alzheimer's Association",

year = "2021",

month = jun,

doi = "10.1002/alz.12250",

language = "English (US)",

volume = "17",

pages = "959--968",

journal = "Alzheimer's and Dementia",

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T1 - Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos

AU - Agudelo, Christian

AU - Tarraf, Wassim

AU - Wu, Benson

AU - Wallace, Douglas M.

AU - Patel, Sanjay R.

AU - Redline, Susan

AU - Kaur, Sonya

AU - Daviglus, Martha

AU - Zee, Phyllis C.

AU - Simonelli, Guido

AU - Mossavar-Rahmani, Yasmin

AU - Sotres-Alvarez, Daniela

AU - Zeng, Donglin

AU - Gallo, Linda C.

AU - González, Hector M.

AU - Ramos, Alberto R.

PY - 2021/6

Y1 - 2021/6

N2 - Introduction: We determined if actigraphy-derived sleep patterns led to 7-year cognitive decline in middle-aged to older Hispanic/Latino adults. Methods: We examined 1035 adults, 45 to 64 years of age, from the Hispanic Community Health Study/Study of Latinos. Participants had repeated measures of cognitive function 7 years apart, home sleep apnea studies, and 1 week of actigraphy. Survey linear regression evaluated prospective associations between sleep and cognitive change, adjusting for main covariates. Results: Longer sleep-onset latency was associated with declines in global cognitive function, verbal learning, and verbal memory. Longer sleep-onset latency was also cross-sectionally associated with verbal learning, verbal memory, and word fluency. Sleep fragmentation was not associated with cognitive change. Conclusion: In a cohort of mostly middle-aged Hispanic/Latinos, actigraphy-derived sleep-onset latency predicted 7-year cognitive change. These findings may serve as targets for sleep interventions of cognitive decline.

AB - Introduction: We determined if actigraphy-derived sleep patterns led to 7-year cognitive decline in middle-aged to older Hispanic/Latino adults. Methods: We examined 1035 adults, 45 to 64 years of age, from the Hispanic Community Health Study/Study of Latinos. Participants had repeated measures of cognitive function 7 years apart, home sleep apnea studies, and 1 week of actigraphy. Survey linear regression evaluated prospective associations between sleep and cognitive change, adjusting for main covariates. Results: Longer sleep-onset latency was associated with declines in global cognitive function, verbal learning, and verbal memory. Longer sleep-onset latency was also cross-sectionally associated with verbal learning, verbal memory, and word fluency. Sleep fragmentation was not associated with cognitive change. Conclusion: In a cohort of mostly middle-aged Hispanic/Latinos, actigraphy-derived sleep-onset latency predicted 7-year cognitive change. These findings may serve as targets for sleep interventions of cognitive decline.

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KW - cognitive decline

KW - cohort studies

KW - risk factors in epidemiology

KW - sleep

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Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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