ACTH Stimulation and Glucocorticoid Inhibition of Renin Release in the Rat

Julia H. Hauger-Klevene, Harold Brown, Norman Fleischer

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

In the rat, ACTH effected a transient rise in the level of plasma renin. Pretreatment with glucocorticoids completely inhibited the ACTH-induced renin rise. After adrenalectomy or inhibition of steroidogenesis by aminoglutethimide. ACTH produced a sustained rise in plasma renin level. Thus in the rat, ACTH has a direct effect on the juxtaglomerular apparatus causing a rise in plasma renin activity and glucocorticoids have an opposing action.

Original languageEnglish (US)
Pages (from-to)539-542
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume131
Issue number2
DOIs
StatePublished - Jun 1969

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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