TY - JOUR
T1 - ACTH Stimulation and Glucocorticoid Inhibition of Renin Release in the Rat
AU - Hauger-Klevene, Julia H.
AU - Brown, Harold
AU - Fleischer, Norman
N1 - Funding Information:
Supported in part by U. S. Public Health Service Grants AM05063, HE05435P20, and FR00134 from the National Institutes of Health. 6 1969 131 2 539 542
PY - 1969/6
Y1 - 1969/6
N2 - In the rat, ACTH effected a transient rise in the level of plasma renin. Pretreatment with glucocorticoids completely inhibited the ACTH-induced renin rise. After adrenalectomy or inhibition of steroidogenesis by aminoglutethimide. ACTH produced a sustained rise in plasma renin level. Thus in the rat, ACTH has a direct effect on the juxtaglomerular apparatus causing a rise in plasma renin activity and glucocorticoids have an opposing action.
AB - In the rat, ACTH effected a transient rise in the level of plasma renin. Pretreatment with glucocorticoids completely inhibited the ACTH-induced renin rise. After adrenalectomy or inhibition of steroidogenesis by aminoglutethimide. ACTH produced a sustained rise in plasma renin level. Thus in the rat, ACTH has a direct effect on the juxtaglomerular apparatus causing a rise in plasma renin activity and glucocorticoids have an opposing action.
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U2 - 10.3181/00379727-131-33920
DO - 10.3181/00379727-131-33920
M3 - Article
C2 - 5787135
AN - SCOPUS:0014525962
SN - 0037-9727
VL - 131
SP - 539
EP - 542
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 2
ER -