Acquired Immunodeficiency With Reversed T4/T8 Ratios in Infants Born to Promiscuous and Drug-Addicted Mothers

Arye Rubinstein, Marc Sicklick, Asha Gupta, Larry Bernstein, Norman Klein, Ethan Rubinstein, Ilya Spigland, Lazar Fruchter, Nathan Litman, Haesoon Lee, Melvin Hollander

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323 Scopus citations


A new syndrome of acquired immunodeficiency has been identified in seven children who were small for gestational age at birth and subsequently have exhibited failure to thrive, lymphadenopathy, parotitis, hepatosplenomegaly, interstitial pneumonia, and recurrent infections. All have a profound cell-mediated immunodeficiency with reversed T4/T8 ratios. Six are hypergammaglobulinemic and one has low IgG levels. The mothers of five of the seven children are sexually promiscuous and/or drug addicts. Three mothers have an immunodeficiency similar to that found in their infants. One of them died at age 33 years with a diagnosis of acquired immunodeficiency syndrome. In five of the children and in three of their mothers, there is evidence of a persistent Epstein-Barr virus (EBV) infection. We speculate that a perinatal or in utero transmission of EBV can induce an “infectious immunodeficiency.” The clinical, histopathologic, and immunologic features resemble those described in adult homosexuals and drug addicts.

Original languageEnglish (US)
Pages (from-to)2350-2356
Number of pages7
JournalJAMA: The Journal of the American Medical Association
Issue number17
Publication statusPublished - May 6 1983


ASJC Scopus subject areas

  • Medicine(all)

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