The mechanism underlying the prolonged activated partial thromboplastin time (APTT) seen in some pediatric patients with acquired immunodeficiency syndrome (AIDS) and opportunistic infections was studied. A circulating inhibitor of coagulation was demonstrated in three patients. The inhibitor appears to be an immunoglobulin that interferes with some of the phospholipid-dependent coagulation reactions of the intrinsic pathway. This 'AIDS anticoagulant' does not predispose the patient to clinical bleeding despite its ability to cause a marked prolongation of the APTT. As such, careful laboratory diagnosis of the cause of abnormal coagulation test results is necessary for children with AIDS.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Jan 1 1988|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health