Acetylcholinesterase levels in skeletal muscle of mice infected with Trypanosoma cruzi

D. J. Brennessel, M. Wittner, V. Braunstein, H. B. Tanowitz

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Acetylcholinesterase (AChE) activity was measured in skeletal muscle from susceptible (A/J) and resistant (C57BL/6) mice infected with the Brazil strain (myotropic) of Trypanosoma cruzi. There was a 60% decrease in activity in skeletal muscle obtained from A/J mice 20 days post-infection as compared to controls. There was no decrease in AChE activity in skeletal muscle obtained from infected C57BL/6 mice 20 and 150 days post-infection. Histologic examination of skeletal muscle from infected A/J mice revealed marked necrosis, pseudocysts, and minimal inflammation. Similar examinations in C57BL/6 mice revealed marked inflammation in the absence of necrosis and parasites. These data provide additional biochemical support that denervation hypersensitivity is an important concomitant of Chagas' disease and that it is already present during the acute stage. Additionally, it may support the notion that the presence of the parasite mediates these abnormalities.

Original languageEnglish (US)
Pages (from-to)460-464
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume34
Issue number3
DOIs
Publication statusPublished - Jan 1 1985

    Fingerprint

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

Cite this