Abstract
Objective: This study was undertaken to evaluate the ability of preoperative endometrial sampling to accurately diagnose high-grade endometrial tumors. Study design: Three hundred sixty endometrial cancer patients had preoperative endometrial sampling and hysterectomy specimens that underwent pathologic review at a single institution from 1995 to 2005. The sensitivity of Pipelle and curettage to diagnose high-grade endometrial tumors (grade 3 endometrioid adenocarcinoma, serous carcinoma, carcinosarcoma, clear cell carcinoma) was determined. Agreement between preoperative and hysterectomy diagnoses was measured by the Kappa statistic. Results: Sensitivity of Pipelle and curettage was 93.8% and 97% in patients with low-grade cancer and 99.2% and 100% in patients with high-grade cancer. Good agreement was observed between the preoperative and the hysterectomy histologic diagnoses (Kappa = 0.69), and between the preoperative and hysterectomy tumor grade (Kappa=0.78). Conclusion: Preoperative endometrial sampling with Pipelle or curettage is sensitive and accurate for the diagnosis of high-grade endometrial tumors, including tumors with nonendometrioid histology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 243.e1-243.e5 |
| Journal | American journal of obstetrics and gynecology |
| Volume | 196 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2007 |
Keywords
- endometrial biopsy
- endometrial carcinoma
- predictive testing
ASJC Scopus subject areas
- Obstetrics and Gynecology
