Accuracy of deformable image registration for contour propagation in adaptive lung radiotherapy

Nicholas Hardcastle, Wouter van Elmpt, Dirk De Ruysscher, Karl Bzdusek, Wolfgang A. Tome

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Deformable image registration (DIR) is an attractive method for automatic propagation of regions of interest (ROIs) in adaptive lung radiotherapy. This study investigates DIR for automatic contour propagation in adaptive Non Small Cell Lung Carcinoma patients.Methods: Pre and mid-treatment fan beam 4D-kVCT scans were taken for 17 NSCLC patients. Gross tumour volumes (GTV), nodal-GTVs, lungs, esophagus and spinal cord were delineated on all kVCT scans. ROIs were propagated from pre- to mid-treatment images using three DIR algorithms. DIR-propagated ROIs were compared with physician-drawn ROIs on the mid-treatment scan using the Dice score and the mean slicewise Hausdorff distance to agreement (MSHD). A physician scored the DIR-propagated ROIs based on clinical utility.Results: Good agreement between the DIR-propagated and physician drawn ROIs was observed for the lungs and spinal cord. Agreement was not as good for the nodal-GTVs and esophagus, due to poor soft-tissue contrast surrounding these structures. 96% of OARs and 85% of target volumes were scored as requiring no or minor adjustments.Conclusions: DIR has been shown to be a clinically useful method for automatic contour propagation in adaptive radiotherapy however thorough assessment of propagated ROIs by the treating physician is recommended.

Original languageEnglish (US)
Article number243
JournalRadiation Oncology
Volume8
Issue number1
DOIs
StatePublished - Oct 18 2013

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Radiotherapy
Physicians
Lung
Esophagus
Spinal Cord
Tumor Burden
Non-Small Cell Lung Carcinoma
Therapeutics

Keywords

  • Adaptive radiotherapy
  • Automatic contour propagation
  • Deformable image registration
  • NSCLC

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Accuracy of deformable image registration for contour propagation in adaptive lung radiotherapy. / Hardcastle, Nicholas; van Elmpt, Wouter; De Ruysscher, Dirk; Bzdusek, Karl; Tome, Wolfgang A.

In: Radiation Oncology, Vol. 8, No. 1, 243, 18.10.2013.

Research output: Contribution to journalArticle

Hardcastle, Nicholas ; van Elmpt, Wouter ; De Ruysscher, Dirk ; Bzdusek, Karl ; Tome, Wolfgang A. / Accuracy of deformable image registration for contour propagation in adaptive lung radiotherapy. In: Radiation Oncology. 2013 ; Vol. 8, No. 1.
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