Abstract
RF/J mice are susceptible to the induction of thymic lymphomas by the carcinogens 3-methylcholanthrene and N-methyl-N-nitrosourea. Given the association of mouse mammary tumor virus (MMTV) with certain thymomas, we examined genomic DNA from chemically induced lymphomas of RF/J mice for new MMTV proviruses. Of 13 tissue culture lines derived from 3-methylcholanthrene-induced tumors, 5 had acquired new proviruses. MMTV amplification coincided with the appearance of viral mRNAs and proteins. However, no primary tumors or animal-passaged tumors contained new proviruses. These observations indicate that MMTV does not have a role in the tumor induction process, although it may become activated and amplified in tissue culture lines derived from tumors.
Original language | English (US) |
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Pages (from-to) | 3200-3204 |
Number of pages | 5 |
Journal | Journal of virology |
Volume | 63 |
Issue number | 7 |
DOIs | |
State | Published - 1989 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology