Absence of mouse mammary tumor virus proviral amplification in chemically induced lymphomas of RF/J mice

R. Kraft, S. T. Ishizaka, S. A. Okenquist, G. Childs, F. Lilly, J. Lenz

Research output: Contribution to journalArticle

Abstract

RF/J mice are susceptible to the induction of thymic lymphomas by the carcinogens 3-methylcholanthrene and N-methyl-N-nitrosourea. Given the association of mouse mammary tumor virus (MMTV) with certain thymomas, we examined genomic DNA from chemically induced lymphomas of RF/J mice for new MMTV proviruses. Of 13 tissue culture lines derived from 3-methylcholanthrene-induced tumors, 5 had acquired new proviruses. MMTV amplification coincided with the appearance of viral mRNAs and proteins. However, no primary tumors or animal-passaged tumors contained new proviruses. These observations indicate that MMTV does not have a role in the tumor induction process, although it may become activated and amplified in tissue culture lines derived from tumors.

Original languageEnglish (US)
Pages (from-to)3200-3204
Number of pages5
JournalJournal of virology
Volume63
Issue number7
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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