Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians

Rod A. Norman, Rudolph L. Leibel, Wendy K. Chung, Loraine Power-Kehoe, Streamson C. Chua, Jr., William C. Knowler, D. Bruce Thompson, Clifton Bogardus, Eric Ravussin

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The homologues of single genes that cause obesity in rodents are suggested as candidate genes for modulation of body composition in humans. Among these genes are the four mouse mutations - diabetes (db), obesity (ob), tubby (tub), and yellow agouti (A(Y)). Variation in the human counterparts to these genes (OB, DB, TUB, and ASP, respectively) may contribute to human obesity, which is thought to have a substantial genetic component. To initially assess the potential contribution of these genes to human obesity, we examined polymorphic DNA markers that, by virtue of syntenic relationships to appropriate regions of the mouse genome, should be closely linked to the human counterparts of these genes. Using combined data from 716 Pima Indians comprising 217 nuclear families, we have tested a number of polymorphic microsatellite markers (three at DB, two at OB, five at TUB, and three at ASP) for sib-pair linkage to BMI, percentage body fat, resting metabolic rate, 24-h energy expenditure, and 24-h respiratory quotient. No significant linkages were found in an analysis of all sibships or in an analysis restricted to discordant sib pairs.

Original languageEnglish (US)
Pages (from-to)1229-1232
Number of pages4
JournalDiabetes
Volume45
Issue number9
StatePublished - 1996
Externally publishedYes

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Potassium Iodide
Energy Metabolism
Rodentia
Obesity
Genes
Basal Metabolism
Body Composition
Nuclear Family
Genetic Markers
Microsatellite Repeats
Adipose Tissue
Genome
Mutation

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Norman, R. A., Leibel, R. L., Chung, W. K., Power-Kehoe, L., Chua, Jr., S. C., Knowler, W. C., ... Ravussin, E. (1996). Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians. Diabetes, 45(9), 1229-1232.

Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians. / Norman, Rod A.; Leibel, Rudolph L.; Chung, Wendy K.; Power-Kehoe, Loraine; Chua, Jr., Streamson C.; Knowler, William C.; Bruce Thompson, D.; Bogardus, Clifton; Ravussin, Eric.

In: Diabetes, Vol. 45, No. 9, 1996, p. 1229-1232.

Research output: Contribution to journalArticle

Norman, RA, Leibel, RL, Chung, WK, Power-Kehoe, L, Chua, Jr., SC, Knowler, WC, Bruce Thompson, D, Bogardus, C & Ravussin, E 1996, 'Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians', Diabetes, vol. 45, no. 9, pp. 1229-1232.
Norman, Rod A. ; Leibel, Rudolph L. ; Chung, Wendy K. ; Power-Kehoe, Loraine ; Chua, Jr., Streamson C. ; Knowler, William C. ; Bruce Thompson, D. ; Bogardus, Clifton ; Ravussin, Eric. / Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians. In: Diabetes. 1996 ; Vol. 45, No. 9. pp. 1229-1232.
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