Absence of Interferon-γ-Inducible Gene IGTP Does Not Significantly Alter the Development of Chagasic Cardiomyopathy in Mice Infected with Trypanosoma cruzi (Brazil Strain)

A. P. De Souza, B. Tang, H. B. Tanowitz, S. M. Factor, V. Shtutin, J. Shirani, G. A. Taylor, Louis M. Weiss, L. A. Jelicks

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Interferon-γ (IFN-γ) contributes to host resistance during acute infection with Trypanosoma cruzi, the causative agent of Chagas' disease. Inducibly expressed guanosine triphosphatase (IGTP), a 48-kDa guanosine triphosphatase (GTPase), is a member of a family of GTPase proteins inducibly expressed by IFN-γ. The expression pattern of IGTP suggests that it may mediate IFN-γ-induced responses in a variety of cell types. IGTP has been demonstrated to be important for control of Toxoplasma gondii infection but not for resistance against Listeria monocytogenes. We evaluated the role of IGTP in development of chronic chagasic cardiomyopathy in IGTP null mice and C57X129sv (wild type [WT]) mice infected with the Brazil strain for 6 mo. There was no significant difference in parasitemia or cardiac histopathology between null and WT mice. Right ventricular remodeling was observed in infected IGTP null mice, suggesting that IGTP does not significantly alter the course of T. cruzi infection.

Original languageEnglish (US)
Pages (from-to)1237-1239
Number of pages3
JournalJournal of Parasitology
Volume89
Issue number6
DOIs
StatePublished - Dec 2003

Fingerprint

Guanosine
Trypanosoma cruzi
cardiomyopathy
guanosinetriphosphatase
interferons
Cardiomyopathies
Interferons
Brazil
gene
mice
Chagas disease
Genes
induced response
histopathology
genes
protein
infection
Ventricular Remodeling
Parasitemia
Chagas Disease

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Parasitology
  • Microbiology

Cite this

Absence of Interferon-γ-Inducible Gene IGTP Does Not Significantly Alter the Development of Chagasic Cardiomyopathy in Mice Infected with Trypanosoma cruzi (Brazil Strain). / De Souza, A. P.; Tang, B.; Tanowitz, H. B.; Factor, S. M.; Shtutin, V.; Shirani, J.; Taylor, G. A.; Weiss, Louis M.; Jelicks, L. A.

In: Journal of Parasitology, Vol. 89, No. 6, 12.2003, p. 1237-1239.

Research output: Contribution to journalArticle

De Souza, A. P. ; Tang, B. ; Tanowitz, H. B. ; Factor, S. M. ; Shtutin, V. ; Shirani, J. ; Taylor, G. A. ; Weiss, Louis M. ; Jelicks, L. A. / Absence of Interferon-γ-Inducible Gene IGTP Does Not Significantly Alter the Development of Chagasic Cardiomyopathy in Mice Infected with Trypanosoma cruzi (Brazil Strain). In: Journal of Parasitology. 2003 ; Vol. 89, No. 6. pp. 1237-1239.
@article{9c271bded02c4ba0a8287f67da0f9b3e,
title = "Absence of Interferon-γ-Inducible Gene IGTP Does Not Significantly Alter the Development of Chagasic Cardiomyopathy in Mice Infected with Trypanosoma cruzi (Brazil Strain)",
abstract = "Interferon-γ (IFN-γ) contributes to host resistance during acute infection with Trypanosoma cruzi, the causative agent of Chagas' disease. Inducibly expressed guanosine triphosphatase (IGTP), a 48-kDa guanosine triphosphatase (GTPase), is a member of a family of GTPase proteins inducibly expressed by IFN-γ. The expression pattern of IGTP suggests that it may mediate IFN-γ-induced responses in a variety of cell types. IGTP has been demonstrated to be important for control of Toxoplasma gondii infection but not for resistance against Listeria monocytogenes. We evaluated the role of IGTP in development of chronic chagasic cardiomyopathy in IGTP null mice and C57X129sv (wild type [WT]) mice infected with the Brazil strain for 6 mo. There was no significant difference in parasitemia or cardiac histopathology between null and WT mice. Right ventricular remodeling was observed in infected IGTP null mice, suggesting that IGTP does not significantly alter the course of T. cruzi infection.",
author = "{De Souza}, {A. P.} and B. Tang and Tanowitz, {H. B.} and Factor, {S. M.} and V. Shtutin and J. Shirani and Taylor, {G. A.} and Weiss, {Louis M.} and Jelicks, {L. A.}",
year = "2003",
month = "12",
doi = "10.1645/GE-3185RN",
language = "English (US)",
volume = "89",
pages = "1237--1239",
journal = "Journal of Parasitology",
issn = "0022-3395",
publisher = "American Society of Parasitologists",
number = "6",

}

TY - JOUR

T1 - Absence of Interferon-γ-Inducible Gene IGTP Does Not Significantly Alter the Development of Chagasic Cardiomyopathy in Mice Infected with Trypanosoma cruzi (Brazil Strain)

AU - De Souza, A. P.

AU - Tang, B.

AU - Tanowitz, H. B.

AU - Factor, S. M.

AU - Shtutin, V.

AU - Shirani, J.

AU - Taylor, G. A.

AU - Weiss, Louis M.

AU - Jelicks, L. A.

PY - 2003/12

Y1 - 2003/12

N2 - Interferon-γ (IFN-γ) contributes to host resistance during acute infection with Trypanosoma cruzi, the causative agent of Chagas' disease. Inducibly expressed guanosine triphosphatase (IGTP), a 48-kDa guanosine triphosphatase (GTPase), is a member of a family of GTPase proteins inducibly expressed by IFN-γ. The expression pattern of IGTP suggests that it may mediate IFN-γ-induced responses in a variety of cell types. IGTP has been demonstrated to be important for control of Toxoplasma gondii infection but not for resistance against Listeria monocytogenes. We evaluated the role of IGTP in development of chronic chagasic cardiomyopathy in IGTP null mice and C57X129sv (wild type [WT]) mice infected with the Brazil strain for 6 mo. There was no significant difference in parasitemia or cardiac histopathology between null and WT mice. Right ventricular remodeling was observed in infected IGTP null mice, suggesting that IGTP does not significantly alter the course of T. cruzi infection.

AB - Interferon-γ (IFN-γ) contributes to host resistance during acute infection with Trypanosoma cruzi, the causative agent of Chagas' disease. Inducibly expressed guanosine triphosphatase (IGTP), a 48-kDa guanosine triphosphatase (GTPase), is a member of a family of GTPase proteins inducibly expressed by IFN-γ. The expression pattern of IGTP suggests that it may mediate IFN-γ-induced responses in a variety of cell types. IGTP has been demonstrated to be important for control of Toxoplasma gondii infection but not for resistance against Listeria monocytogenes. We evaluated the role of IGTP in development of chronic chagasic cardiomyopathy in IGTP null mice and C57X129sv (wild type [WT]) mice infected with the Brazil strain for 6 mo. There was no significant difference in parasitemia or cardiac histopathology between null and WT mice. Right ventricular remodeling was observed in infected IGTP null mice, suggesting that IGTP does not significantly alter the course of T. cruzi infection.

UR - http://www.scopus.com/inward/record.url?scp=0346998051&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346998051&partnerID=8YFLogxK

U2 - 10.1645/GE-3185RN

DO - 10.1645/GE-3185RN

M3 - Article

C2 - 14740917

AN - SCOPUS:0346998051

VL - 89

SP - 1237

EP - 1239

JO - Journal of Parasitology

JF - Journal of Parasitology

SN - 0022-3395

IS - 6

ER -