Abnormal pattern electroretinogram in Alzheimer's disease: Evidence for retinal ganglion cell degeneration?

Barrett Katz, S. Rimmer, V. Iragui, R. Katzman

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

We recorded pattern-reversal electroretinograms, flash electroretinograms, pattern-reversal visual evoked potentials, and flash visual evoked potentials in 6 patients with clinically diagnosed Alzheimer's disease and 6 age- and sex-matched control subjects. The mean amplitude of the pattern-reversal electroretinogram in the Alzheimer patients was significantly less than that of the control group (p = 0.004). This anomaly of the pattern-reversal electroretinogram may be a reflection of documented axonal depletion within the optic nerve and the degeneration of retinal ganglion cells seen in Alzheimer's disease. We found Alzheimer patients to have normal pattern-reversal visual evoked potentials and flash electroretinograms, but a delayed second positive component of the flash visual evoked potential. This combination of findings may be of diagnostic import in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)221-225
Number of pages5
JournalAnnals of Neurology
Volume26
Issue number2
StatePublished - 1989
Externally publishedYes

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Visual Evoked Potentials
Retinal Ganglion Cells
Alzheimer Disease
Nerve Degeneration
Optic Nerve
Control Groups

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Abnormal pattern electroretinogram in Alzheimer's disease : Evidence for retinal ganglion cell degeneration? / Katz, Barrett; Rimmer, S.; Iragui, V.; Katzman, R.

In: Annals of Neurology, Vol. 26, No. 2, 1989, p. 221-225.

Research output: Contribution to journalArticle

Katz, Barrett ; Rimmer, S. ; Iragui, V. ; Katzman, R. / Abnormal pattern electroretinogram in Alzheimer's disease : Evidence for retinal ganglion cell degeneration?. In: Annals of Neurology. 1989 ; Vol. 26, No. 2. pp. 221-225.
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