Abnormal Biochemical Analytes Used for Aneuploidy Screening and Adverse Pregnancy Outcomes in Twin Gestations

Jonathan Y. Rosner, Nathan S. Fox, Daniel Saltzman, Chad K. Klauser, Andrei Rebarber, Simi Gupta

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Objective The objective of this study was to determine if first- and second-trimester biochemical markers for aneuploidy have an association with adverse pregnancy outcomes in twin gestations. Study Design A retrospective cohort study of patients who presented with dichorionic diamniotic twin gestations was performed. Patients with first-trimester low pregnancy-associated plasma protein A (PAPP-A) or low free β human chorionic gonadotropin (β-hCG), or second-trimester elevated α-fetoprotein (AFP), elevated inhibin A, elevated hCG, or low unconjugated estradiol were identified. The rates of adverse pregnancy outcomes were compared between patients with or without abnormal analytes with p <0.05 used as significance. Results In this study, 340 pregnancies were included. Patients with a low PAPP-A had an increased risk for delivery <37 weeks. Patients with an elevated second-trimester hCG had an increased risk for spontaneous delivery <28 weeks and neonatal intensive care unit (NICU) admission. Patients with an elevated inhibin A had an increased risk of spontaneous delivery at <37 and NICU admission. Patients with an elevated AFP had an increased risk of a NICU admission. Conclusion Certain abnormal aneuploidy markers are associated with an increased risk of adverse pregnancy outcomes in twin gestations.

Original languageEnglish (US)
Pages (from-to)1331-1335
Number of pages5
JournalAmerican Journal of Perinatology
Volume32
Issue number14
DOIs
StatePublished - Sep 16 2015

Keywords

  • adverse outcomes
  • analytes
  • twins

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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