Barrett's esophagus (BE) is a condition in which the stratified squamous epithelium that normally lines the distal esophagus lumen is replaced by metaplastic columnar epithelium that has both gastric and intestinal features. It is usually caused by persistent damage to the esophageal mucosa due to long-standing gastroesophageal reflux disease (GERD) and predisposes patients to esophageal adenocarcinoma (EAC), a cancer with a significantly increasing incidence over the past 40 years. While there are several risk factors for EAC, including smoking and obesity, GERD is the most significant one. Patients with BE have an estimated 30-125-fold greater chance of developing EAC compared to the general population.
|Original language||English (US)|
|Title of host publication||Benign Esophageal Disease|
|Subtitle of host publication||Modern Surgical Approaches and Techniques|
|Number of pages||7|
|State||Published - Apr 12 2021|
ASJC Scopus subject areas