TY - JOUR
T1 - Aberrant de novo cholesterogenesis
T2 - Clinical significance and implications
AU - Rashid, Rida
AU - Ameer, Fatima
AU - Kalbacher, Hubert
AU - Scandiuzzi, Lisa
AU - Zaidi, Nousheen
N1 - Funding Information:
We are grateful to Prof. Dr. Graham Pawelec for the critical review of this article. His valuable and insightful comments helped us to substantially improve this manuscript. The work was supported by the National Research Program for Universities of the Higher Education Commission Pakistan (Project # 2505/R&D/11-2670 ) (PI; N. Zaidi), DAAD -Re-invitation Program for Former Scholarship Holders, 2015 ( 50068612 ), Personal Ref. no. 91563417 and Punjab University Annual Grant (2015) (PI; N. Zaidi).
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/10/23
Y1 - 2015/10/23
N2 - Human cells can acquire cholesterol from the circulation but also have the ability to synthesize it via de novo cholesterogenesis (DC). Cholesterol absorption and de novo cholesterogenesis are the key processes that modulate cholesterol homeostasis in the human body. The endogenous biosynthesis of cholesterol substantially contributes to the whole-body cholesterol pool. Additionally, dysregulation of this pathway is associated with diverse medical conditions. The present review focuses on our current understanding of the cholesterogenic pathway and the various different factors regulating this pathway. It also highlights dysregulation of this pathway in various physiological and pathological conditions including cardiovascular diseases, type II diabetes, obesity and viral infections.
AB - Human cells can acquire cholesterol from the circulation but also have the ability to synthesize it via de novo cholesterogenesis (DC). Cholesterol absorption and de novo cholesterogenesis are the key processes that modulate cholesterol homeostasis in the human body. The endogenous biosynthesis of cholesterol substantially contributes to the whole-body cholesterol pool. Additionally, dysregulation of this pathway is associated with diverse medical conditions. The present review focuses on our current understanding of the cholesterogenic pathway and the various different factors regulating this pathway. It also highlights dysregulation of this pathway in various physiological and pathological conditions including cardiovascular diseases, type II diabetes, obesity and viral infections.
KW - Cholesterol absorption
KW - De novo cholesterol synthesis
KW - Mevalonate pathway
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U2 - 10.1016/j.cca.2015.09.014
DO - 10.1016/j.cca.2015.09.014
M3 - Review article
C2 - 26386164
AN - SCOPUS:84944128830
SN - 0009-8981
VL - 450
SP - 356
EP - 361
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
ER -
