Aberrant de novo cholesterogenesis: Clinical significance and implications

Rida Rashid, Fatima Ameer, Hubert Kalbacher, Lisa Scandiuzzi, Nousheen Zaidi

Research output: Contribution to journalArticle

Abstract

Human cells can acquire cholesterol from the circulation but also have the ability to synthesize it via de novo cholesterogenesis (DC). Cholesterol absorption and de novo cholesterogenesis are the key processes that modulate cholesterol homeostasis in the human body. The endogenous biosynthesis of cholesterol substantially contributes to the whole-body cholesterol pool. Additionally, dysregulation of this pathway is associated with diverse medical conditions. The present review focuses on our current understanding of the cholesterogenic pathway and the various different factors regulating this pathway. It also highlights dysregulation of this pathway in various physiological and pathological conditions including cardiovascular diseases, type II diabetes, obesity and viral infections.

Original languageEnglish (US)
Pages (from-to)356-361
Number of pages6
JournalClinica Chimica Acta
Volume450
DOIs
StatePublished - Oct 23 2015
Externally publishedYes

Fingerprint

Cholesterol
Biosynthesis
Virus Diseases
Medical problems
Human Body
Type 2 Diabetes Mellitus
Homeostasis
Cardiovascular Diseases
Obesity
Cells

Keywords

  • Cholesterol absorption
  • De novo cholesterol synthesis
  • Mevalonate pathway

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Rashid, R., Ameer, F., Kalbacher, H., Scandiuzzi, L., & Zaidi, N. (2015). Aberrant de novo cholesterogenesis: Clinical significance and implications. Clinica Chimica Acta, 450, 356-361. https://doi.org/10.1016/j.cca.2015.09.014

Aberrant de novo cholesterogenesis : Clinical significance and implications. / Rashid, Rida; Ameer, Fatima; Kalbacher, Hubert; Scandiuzzi, Lisa; Zaidi, Nousheen.

In: Clinica Chimica Acta, Vol. 450, 23.10.2015, p. 356-361.

Research output: Contribution to journalArticle

Rashid, R, Ameer, F, Kalbacher, H, Scandiuzzi, L & Zaidi, N 2015, 'Aberrant de novo cholesterogenesis: Clinical significance and implications', Clinica Chimica Acta, vol. 450, pp. 356-361. https://doi.org/10.1016/j.cca.2015.09.014
Rashid, Rida ; Ameer, Fatima ; Kalbacher, Hubert ; Scandiuzzi, Lisa ; Zaidi, Nousheen. / Aberrant de novo cholesterogenesis : Clinical significance and implications. In: Clinica Chimica Acta. 2015 ; Vol. 450. pp. 356-361.
@article{f66dc25f542446c8a73f300e708b8e06,
title = "Aberrant de novo cholesterogenesis: Clinical significance and implications",
abstract = "Human cells can acquire cholesterol from the circulation but also have the ability to synthesize it via de novo cholesterogenesis (DC). Cholesterol absorption and de novo cholesterogenesis are the key processes that modulate cholesterol homeostasis in the human body. The endogenous biosynthesis of cholesterol substantially contributes to the whole-body cholesterol pool. Additionally, dysregulation of this pathway is associated with diverse medical conditions. The present review focuses on our current understanding of the cholesterogenic pathway and the various different factors regulating this pathway. It also highlights dysregulation of this pathway in various physiological and pathological conditions including cardiovascular diseases, type II diabetes, obesity and viral infections.",
keywords = "Cholesterol absorption, De novo cholesterol synthesis, Mevalonate pathway",
author = "Rida Rashid and Fatima Ameer and Hubert Kalbacher and Lisa Scandiuzzi and Nousheen Zaidi",
year = "2015",
month = "10",
day = "23",
doi = "10.1016/j.cca.2015.09.014",
language = "English (US)",
volume = "450",
pages = "356--361",
journal = "Clinica Chimica Acta",
issn = "0009-8981",
publisher = "Elsevier",

}

TY - JOUR

T1 - Aberrant de novo cholesterogenesis

T2 - Clinical significance and implications

AU - Rashid, Rida

AU - Ameer, Fatima

AU - Kalbacher, Hubert

AU - Scandiuzzi, Lisa

AU - Zaidi, Nousheen

PY - 2015/10/23

Y1 - 2015/10/23

N2 - Human cells can acquire cholesterol from the circulation but also have the ability to synthesize it via de novo cholesterogenesis (DC). Cholesterol absorption and de novo cholesterogenesis are the key processes that modulate cholesterol homeostasis in the human body. The endogenous biosynthesis of cholesterol substantially contributes to the whole-body cholesterol pool. Additionally, dysregulation of this pathway is associated with diverse medical conditions. The present review focuses on our current understanding of the cholesterogenic pathway and the various different factors regulating this pathway. It also highlights dysregulation of this pathway in various physiological and pathological conditions including cardiovascular diseases, type II diabetes, obesity and viral infections.

AB - Human cells can acquire cholesterol from the circulation but also have the ability to synthesize it via de novo cholesterogenesis (DC). Cholesterol absorption and de novo cholesterogenesis are the key processes that modulate cholesterol homeostasis in the human body. The endogenous biosynthesis of cholesterol substantially contributes to the whole-body cholesterol pool. Additionally, dysregulation of this pathway is associated with diverse medical conditions. The present review focuses on our current understanding of the cholesterogenic pathway and the various different factors regulating this pathway. It also highlights dysregulation of this pathway in various physiological and pathological conditions including cardiovascular diseases, type II diabetes, obesity and viral infections.

KW - Cholesterol absorption

KW - De novo cholesterol synthesis

KW - Mevalonate pathway

UR - http://www.scopus.com/inward/record.url?scp=84944128830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944128830&partnerID=8YFLogxK

U2 - 10.1016/j.cca.2015.09.014

DO - 10.1016/j.cca.2015.09.014

M3 - Article

C2 - 26386164

AN - SCOPUS:84944128830

VL - 450

SP - 356

EP - 361

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

ER -