Abdominal obesity, race and chronic kidney disease in young adults: Results from NHANES 1999-2010

Harini Sarathy, Gabriela Henriquez, Matthew K. Abramowitz, Holly Kramer, Sylvia E. Rosas, Tanya S. Johns, Juhi Kumar, Amy Skversky, Frederick J. Kaskel, Michal L. Melamed

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: Kidney dysfunction in obesity may be independent of and may precede the development of hypertension and/or diabetes mellitus. We aimed to examine if abdominal obesity is associated with early markers of CKD in a young healthy population and whether these associations differ by race and/or ethnicity. Methods: We analyzed data from the NHANES 1999-2010 for 6918 young adults ages 20-40 years. Abdominal obesity was defined by gender criteria of waist circumference. CKD markers included estimated glomerular filtration rate and albuminuria ≥30 mg/g. Race stratified analyses were done overall and in subgroups with normal blood pressures, normoglycemia and normal insulin sensitivity. Awareness of CKD was assessed in participants with albuminuria. Results: Abdominal obesity was present in over one-third of all young adults and was more prevalent among non-Hispanic blacks (45.4%) versus Mexican-Americans (40.6%) or non-Hispanic whites (37.4%) (P-value = 0.004). Mexican-American young adults with abdominal obesity had a higher odds of albuminuria even among those with normal blood pressure, normal glucose, and normal insulin sensitivity [adjusted odds ratio 4.5; 95% confidence interval (1.6-12.2), p = 0.004]. Less than 5% of young adults with albuminuria of all races and ethnicities had been told they had kidney disease. Conclusion: Abdominal obesity in young adults, especially in Mexican-Americans, is independently associated with albuminuria even with normal blood pressures, normoglycemia and normal insulin levels. Greater awareness of CKD is needed to protect this young population from long-standing exposure to abdominal obesity and early progressive renal disease.

Original languageEnglish (US)
Article numbere0153588
JournalPLoS One
Volume11
Issue number5
DOIs
StatePublished - May 1 2016

Fingerprint

National Health and Nutrition Examination Survey
Abdominal Obesity
Nutrition Surveys
Blood pressure
kidney diseases
Albuminuria
Chronic Renal Insufficiency
young adults
Young Adult
obesity
Insulin
Mexican Americans
blood pressure
Medical problems
Blood Pressure
Insulin Resistance
nationalities and ethnic groups
insulin resistance
Kidney
Glucose

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Abdominal obesity, race and chronic kidney disease in young adults : Results from NHANES 1999-2010. / Sarathy, Harini; Henriquez, Gabriela; Abramowitz, Matthew K.; Kramer, Holly; Rosas, Sylvia E.; Johns, Tanya S.; Kumar, Juhi; Skversky, Amy; Kaskel, Frederick J.; Melamed, Michal L.

In: PLoS One, Vol. 11, No. 5, e0153588, 01.05.2016.

Research output: Contribution to journalArticle

Sarathy, Harini ; Henriquez, Gabriela ; Abramowitz, Matthew K. ; Kramer, Holly ; Rosas, Sylvia E. ; Johns, Tanya S. ; Kumar, Juhi ; Skversky, Amy ; Kaskel, Frederick J. ; Melamed, Michal L. / Abdominal obesity, race and chronic kidney disease in young adults : Results from NHANES 1999-2010. In: PLoS One. 2016 ; Vol. 11, No. 5.
@article{55e0b1bd36f04e63b60545e775557a82,
title = "Abdominal obesity, race and chronic kidney disease in young adults: Results from NHANES 1999-2010",
abstract = "Objective: Kidney dysfunction in obesity may be independent of and may precede the development of hypertension and/or diabetes mellitus. We aimed to examine if abdominal obesity is associated with early markers of CKD in a young healthy population and whether these associations differ by race and/or ethnicity. Methods: We analyzed data from the NHANES 1999-2010 for 6918 young adults ages 20-40 years. Abdominal obesity was defined by gender criteria of waist circumference. CKD markers included estimated glomerular filtration rate and albuminuria ≥30 mg/g. Race stratified analyses were done overall and in subgroups with normal blood pressures, normoglycemia and normal insulin sensitivity. Awareness of CKD was assessed in participants with albuminuria. Results: Abdominal obesity was present in over one-third of all young adults and was more prevalent among non-Hispanic blacks (45.4{\%}) versus Mexican-Americans (40.6{\%}) or non-Hispanic whites (37.4{\%}) (P-value = 0.004). Mexican-American young adults with abdominal obesity had a higher odds of albuminuria even among those with normal blood pressure, normal glucose, and normal insulin sensitivity [adjusted odds ratio 4.5; 95{\%} confidence interval (1.6-12.2), p = 0.004]. Less than 5{\%} of young adults with albuminuria of all races and ethnicities had been told they had kidney disease. Conclusion: Abdominal obesity in young adults, especially in Mexican-Americans, is independently associated with albuminuria even with normal blood pressures, normoglycemia and normal insulin levels. Greater awareness of CKD is needed to protect this young population from long-standing exposure to abdominal obesity and early progressive renal disease.",
author = "Harini Sarathy and Gabriela Henriquez and Abramowitz, {Matthew K.} and Holly Kramer and Rosas, {Sylvia E.} and Johns, {Tanya S.} and Juhi Kumar and Amy Skversky and Kaskel, {Frederick J.} and Melamed, {Michal L.}",
year = "2016",
month = "5",
day = "1",
doi = "10.1371/journal.pone.0153588",
language = "English (US)",
volume = "11",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

TY - JOUR

T1 - Abdominal obesity, race and chronic kidney disease in young adults

T2 - Results from NHANES 1999-2010

AU - Sarathy, Harini

AU - Henriquez, Gabriela

AU - Abramowitz, Matthew K.

AU - Kramer, Holly

AU - Rosas, Sylvia E.

AU - Johns, Tanya S.

AU - Kumar, Juhi

AU - Skversky, Amy

AU - Kaskel, Frederick J.

AU - Melamed, Michal L.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Objective: Kidney dysfunction in obesity may be independent of and may precede the development of hypertension and/or diabetes mellitus. We aimed to examine if abdominal obesity is associated with early markers of CKD in a young healthy population and whether these associations differ by race and/or ethnicity. Methods: We analyzed data from the NHANES 1999-2010 for 6918 young adults ages 20-40 years. Abdominal obesity was defined by gender criteria of waist circumference. CKD markers included estimated glomerular filtration rate and albuminuria ≥30 mg/g. Race stratified analyses were done overall and in subgroups with normal blood pressures, normoglycemia and normal insulin sensitivity. Awareness of CKD was assessed in participants with albuminuria. Results: Abdominal obesity was present in over one-third of all young adults and was more prevalent among non-Hispanic blacks (45.4%) versus Mexican-Americans (40.6%) or non-Hispanic whites (37.4%) (P-value = 0.004). Mexican-American young adults with abdominal obesity had a higher odds of albuminuria even among those with normal blood pressure, normal glucose, and normal insulin sensitivity [adjusted odds ratio 4.5; 95% confidence interval (1.6-12.2), p = 0.004]. Less than 5% of young adults with albuminuria of all races and ethnicities had been told they had kidney disease. Conclusion: Abdominal obesity in young adults, especially in Mexican-Americans, is independently associated with albuminuria even with normal blood pressures, normoglycemia and normal insulin levels. Greater awareness of CKD is needed to protect this young population from long-standing exposure to abdominal obesity and early progressive renal disease.

AB - Objective: Kidney dysfunction in obesity may be independent of and may precede the development of hypertension and/or diabetes mellitus. We aimed to examine if abdominal obesity is associated with early markers of CKD in a young healthy population and whether these associations differ by race and/or ethnicity. Methods: We analyzed data from the NHANES 1999-2010 for 6918 young adults ages 20-40 years. Abdominal obesity was defined by gender criteria of waist circumference. CKD markers included estimated glomerular filtration rate and albuminuria ≥30 mg/g. Race stratified analyses were done overall and in subgroups with normal blood pressures, normoglycemia and normal insulin sensitivity. Awareness of CKD was assessed in participants with albuminuria. Results: Abdominal obesity was present in over one-third of all young adults and was more prevalent among non-Hispanic blacks (45.4%) versus Mexican-Americans (40.6%) or non-Hispanic whites (37.4%) (P-value = 0.004). Mexican-American young adults with abdominal obesity had a higher odds of albuminuria even among those with normal blood pressure, normal glucose, and normal insulin sensitivity [adjusted odds ratio 4.5; 95% confidence interval (1.6-12.2), p = 0.004]. Less than 5% of young adults with albuminuria of all races and ethnicities had been told they had kidney disease. Conclusion: Abdominal obesity in young adults, especially in Mexican-Americans, is independently associated with albuminuria even with normal blood pressures, normoglycemia and normal insulin levels. Greater awareness of CKD is needed to protect this young population from long-standing exposure to abdominal obesity and early progressive renal disease.

UR - http://www.scopus.com/inward/record.url?scp=84971455146&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84971455146&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0153588

DO - 10.1371/journal.pone.0153588

M3 - Article

C2 - 27224643

AN - SCOPUS:84971455146

VL - 11

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 5

M1 - e0153588

ER -