@article{4f3f14a784d445ff9526ba179c9ed34c,
title = "Abdominal fat depots, insulin resistance, and incident diabetes mellitus in women with and without HIV infection",
abstract = "Objective: The aim of this study was to determine the associations between visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) mass with homeostatic model assessment-insulin resistance (HOMA-IR) and incidence of diabetes mellitus in women with and without HIV infection. Design: Cross-sectional design for associations between abdominal fat and HOMA-IR; longitudinal design for associations between abdominal fat and incident diabetes. Methods: We assessed associations between dual X-ray absorptiometry scan-derived VAT and SAT with HOMA-IR in a subsample from the Women's Interagency HIV Study (n=226 with and n=100 without HIV) using linear regression. We evaluated associations of VAT, SAT and HOMA-IR with incident diabetes mellitus using Cox proportional hazards models. Results: VAT mass was positively associated with log HOMA-IR in fully adjusted linear regression models stratified by HIV serostatus, including adjustment for SAT. During median follow-up of 10.6 years, incidence of diabetes was 1.63 [95% confidence interval (95% CI) 1.15-2.31] and 1.32 [95% CI 0.77-2.28] cases per 100 person-years in women with and without HIV (P=0.52). In a fully adjusted model, baseline VAT (hazard ratio 2.64 per kg; 95% CI 1.14-6.12; P=0.023) and SAT (hazard ratio 1.34 per kg; 95% CI 0.73-2.45; P=0.35) were associated with incident diabetes, but the latter was not statistically significant. Conclusion: VAT mass was independently associated with HOMA-IR in women with and without HIV and was independently associated with future development of diabetes.",
keywords = "Diabetes mellitus, HIV-1, Insulin resistance, Subcutaneous adipose tissue, Visceral adipose tissue, Women",
author = "Glesby, {Marshall J.} and Hanna, {David B.} and Hoover, {Donald R.} and Qiuhu Shi and Yin, {Michael T.} and Tien, {Phyllis C.} and Mardge Cohen and Kathryn Anastos and Anjali Sharma",
note = "Funding Information: Data in this manuscript were collected by three sites of the WIHS. The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). WIHS (Principal Investigators): Bronx WIHS (Kathryn Anastos and Anjali Sharma), U01-AI-035004; Chicago WIHS (Mardge Cohen and Audrey French), U01-AI-034993; Connie Wofsy Women{\textquoteright}s HIV Study, Northern California (Ruth Greenblatt, Bradley Aouizerat, and Phyllis Tien), U01-AI-034989; WIHS Data Management and Analysis Center (Stephen Gange and Elizabeth Golub), U01-AI-042590. The WIHS is funded primarily by the National Institute of Allergy and Infectious Diseases (NIAID), with additional co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Cancer Institute (NCI), the National Institute on Drug Abuse (NIDA), and the National Institute on Mental Health (NIMH). Targeted supplemental funding for specific projects is also provided by the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute on Deafness and other Communication Disorders (NIDCD) and the NIH Office of Research on Women{\textquoteright}s Health. WIHS data collection is also supported by UL1-TR000004 (UCSF CTSA). D.B.H., A.S. and P.C.T. were supported by K01 HL137557, K23 AR06199301 and K24 AI108516, respectively. Analysis of the DXA scans was supported by a supplement from the National Institute of Aging. Funding Information: Data in this manuscript were collected by three sites of the WIHS. The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). WIHS (Principal Investigators): Bronx WIHS (Kathryn Anastos and Anjali Sharma), U01-AI-035004; Chicago WIHS (Mardge Cohen and Audrey French), U01-AI-034993; Connie Wofsy Women's HIV Study, Northern California (Ruth Greenblatt, Bradley Aouizerat, and Phyllis Tien), U01-AI-034989; WIHS Data Management and Analysis Center (Stephen Gange and Elizabeth Golub), U01-AI-042590. The WIHS is funded primarily by the National Institute of Allergy and Infectious Diseases (NIAID), with additional co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Cancer Institute (NCI), the National Institute on Drug Abuse (NIDA), and the National Institute on Mental Health (NIMH). Targeted supplemental funding for specific projects is also provided by the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute on Deafness and other Communication Disorders (NIDCD) and the NIH Office of Research on Women's Health. WIHS data collection is also supported by UL1-TR000004 (UCSF CTSA). D.B.H., A.S. and P.C.T. were supported by K01 HL137557, K23 AR06199301 and K24 AI108516, respectively. Analysis of the DXA scans was supported by a supplement from the National Institute of Aging. Publisher Copyright: {\textcopyright} 2018 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2018",
doi = "10.1097/QAD.0000000000001873",
language = "English (US)",
volume = "32",
pages = "1643--1650",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams and Wilkins",
number = "12",
}
