Abstract
Objective: The aim of this study was to determine the associations between visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) mass with homeostatic model assessment-insulin resistance (HOMA-IR) and incidence of diabetes mellitus in women with and without HIV infection. Design: Cross-sectional design for associations between abdominal fat and HOMA-IR; longitudinal design for associations between abdominal fat and incident diabetes. Methods: We assessed associations between dual X-ray absorptiometry scan-derived VAT and SAT with HOMA-IR in a subsample from the Women's Interagency HIV Study (n=226 with and n=100 without HIV) using linear regression. We evaluated associations of VAT, SAT and HOMA-IR with incident diabetes mellitus using Cox proportional hazards models. Results: VAT mass was positively associated with log HOMA-IR in fully adjusted linear regression models stratified by HIV serostatus, including adjustment for SAT. During median follow-up of 10.6 years, incidence of diabetes was 1.63 [95% confidence interval (95% CI) 1.15-2.31] and 1.32 [95% CI 0.77-2.28] cases per 100 person-years in women with and without HIV (P=0.52). In a fully adjusted model, baseline VAT (hazard ratio 2.64 per kg; 95% CI 1.14-6.12; P=0.023) and SAT (hazard ratio 1.34 per kg; 95% CI 0.73-2.45; P=0.35) were associated with incident diabetes, but the latter was not statistically significant. Conclusion: VAT mass was independently associated with HOMA-IR in women with and without HIV and was independently associated with future development of diabetes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1643-1650 |
| Number of pages | 8 |
| Journal | AIDS |
| Volume | 32 |
| Issue number | 12 |
| DOIs | |
| State | Published - Jan 1 2018 |
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Keywords
- Diabetes mellitus
- HIV-1
- Insulin resistance
- Subcutaneous adipose tissue
- Visceral adipose tissue
- Women
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases
Cite this
Abdominal fat depots, insulin resistance, and incident diabetes mellitus in women with and without HIV infection. / Glesby, Marshall J.; Hanna, David B.; Hoover, Donald R.; Shi, Qiuhu; Yin, Michael T.; Tien, Phyllis C.; Cohen, Mardge; Anastos, Kathryn; Sharma, Anjali.
In: AIDS, Vol. 32, No. 12, 01.01.2018, p. 1643-1650.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Abdominal fat depots, insulin resistance, and incident diabetes mellitus in women with and without HIV infection
AU - Glesby, Marshall J.
AU - Hanna, David B.
AU - Hoover, Donald R.
AU - Shi, Qiuhu
AU - Yin, Michael T.
AU - Tien, Phyllis C.
AU - Cohen, Mardge
AU - Anastos, Kathryn
AU - Sharma, Anjali
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Objective: The aim of this study was to determine the associations between visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) mass with homeostatic model assessment-insulin resistance (HOMA-IR) and incidence of diabetes mellitus in women with and without HIV infection. Design: Cross-sectional design for associations between abdominal fat and HOMA-IR; longitudinal design for associations between abdominal fat and incident diabetes. Methods: We assessed associations between dual X-ray absorptiometry scan-derived VAT and SAT with HOMA-IR in a subsample from the Women's Interagency HIV Study (n=226 with and n=100 without HIV) using linear regression. We evaluated associations of VAT, SAT and HOMA-IR with incident diabetes mellitus using Cox proportional hazards models. Results: VAT mass was positively associated with log HOMA-IR in fully adjusted linear regression models stratified by HIV serostatus, including adjustment for SAT. During median follow-up of 10.6 years, incidence of diabetes was 1.63 [95% confidence interval (95% CI) 1.15-2.31] and 1.32 [95% CI 0.77-2.28] cases per 100 person-years in women with and without HIV (P=0.52). In a fully adjusted model, baseline VAT (hazard ratio 2.64 per kg; 95% CI 1.14-6.12; P=0.023) and SAT (hazard ratio 1.34 per kg; 95% CI 0.73-2.45; P=0.35) were associated with incident diabetes, but the latter was not statistically significant. Conclusion: VAT mass was independently associated with HOMA-IR in women with and without HIV and was independently associated with future development of diabetes.
AB - Objective: The aim of this study was to determine the associations between visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) mass with homeostatic model assessment-insulin resistance (HOMA-IR) and incidence of diabetes mellitus in women with and without HIV infection. Design: Cross-sectional design for associations between abdominal fat and HOMA-IR; longitudinal design for associations between abdominal fat and incident diabetes. Methods: We assessed associations between dual X-ray absorptiometry scan-derived VAT and SAT with HOMA-IR in a subsample from the Women's Interagency HIV Study (n=226 with and n=100 without HIV) using linear regression. We evaluated associations of VAT, SAT and HOMA-IR with incident diabetes mellitus using Cox proportional hazards models. Results: VAT mass was positively associated with log HOMA-IR in fully adjusted linear regression models stratified by HIV serostatus, including adjustment for SAT. During median follow-up of 10.6 years, incidence of diabetes was 1.63 [95% confidence interval (95% CI) 1.15-2.31] and 1.32 [95% CI 0.77-2.28] cases per 100 person-years in women with and without HIV (P=0.52). In a fully adjusted model, baseline VAT (hazard ratio 2.64 per kg; 95% CI 1.14-6.12; P=0.023) and SAT (hazard ratio 1.34 per kg; 95% CI 0.73-2.45; P=0.35) were associated with incident diabetes, but the latter was not statistically significant. Conclusion: VAT mass was independently associated with HOMA-IR in women with and without HIV and was independently associated with future development of diabetes.
KW - Diabetes mellitus
KW - HIV-1
KW - Insulin resistance
KW - Subcutaneous adipose tissue
KW - Visceral adipose tissue
KW - Women
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U2 - 10.1097/QAD.0000000000001873
DO - 10.1097/QAD.0000000000001873
M3 - Article
VL - 32
SP - 1643
EP - 1650
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 12
ER -