Abdominal fat depots, insulin resistance, and incident diabetes mellitus in women with and without HIV infection

Marshall J. Glesby, David B. Hanna, Donald R. Hoover, Qiuhu Shi, Michael T. Yin, Phyllis C. Tien, Mardge Cohen, Kathryn Anastos, Anjali Sharma

Research output: Contribution to journalArticle

Abstract

Objective: The aim of this study was to determine the associations between visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) mass with homeostatic model assessment-insulin resistance (HOMA-IR) and incidence of diabetes mellitus in women with and without HIV infection. Design: Cross-sectional design for associations between abdominal fat and HOMA-IR; longitudinal design for associations between abdominal fat and incident diabetes. Methods: We assessed associations between dual X-ray absorptiometry scan-derived VAT and SAT with HOMA-IR in a subsample from the Women's Interagency HIV Study (n=226 with and n=100 without HIV) using linear regression. We evaluated associations of VAT, SAT and HOMA-IR with incident diabetes mellitus using Cox proportional hazards models. Results: VAT mass was positively associated with log HOMA-IR in fully adjusted linear regression models stratified by HIV serostatus, including adjustment for SAT. During median follow-up of 10.6 years, incidence of diabetes was 1.63 [95% confidence interval (95% CI) 1.15-2.31] and 1.32 [95% CI 0.77-2.28] cases per 100 person-years in women with and without HIV (P=0.52). In a fully adjusted model, baseline VAT (hazard ratio 2.64 per kg; 95% CI 1.14-6.12; P=0.023) and SAT (hazard ratio 1.34 per kg; 95% CI 0.73-2.45; P=0.35) were associated with incident diabetes, but the latter was not statistically significant. Conclusion: VAT mass was independently associated with HOMA-IR in women with and without HIV and was independently associated with future development of diabetes.

LanguageEnglish (US)
Pages1643-1650
Number of pages8
JournalAIDS
Volume32
Issue number12
DOIs
StatePublished - Jan 1 2018

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Abdominal Fat
Intra-Abdominal Fat
HIV Infections
Insulin Resistance
Diabetes Mellitus
Subcutaneous Fat
HIV
Confidence Intervals
Linear Models
Abdominal Subcutaneous Fat
Incidence
Photon Absorptiometry
Proportional Hazards Models
depot-insulin

Keywords

  • Diabetes mellitus
  • HIV-1
  • Insulin resistance
  • Subcutaneous adipose tissue
  • Visceral adipose tissue
  • Women

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Abdominal fat depots, insulin resistance, and incident diabetes mellitus in women with and without HIV infection. / Glesby, Marshall J.; Hanna, David B.; Hoover, Donald R.; Shi, Qiuhu; Yin, Michael T.; Tien, Phyllis C.; Cohen, Mardge; Anastos, Kathryn; Sharma, Anjali.

In: AIDS, Vol. 32, No. 12, 01.01.2018, p. 1643-1650.

Research output: Contribution to journalArticle

Glesby, Marshall J. ; Hanna, David B. ; Hoover, Donald R. ; Shi, Qiuhu ; Yin, Michael T. ; Tien, Phyllis C. ; Cohen, Mardge ; Anastos, Kathryn ; Sharma, Anjali. / Abdominal fat depots, insulin resistance, and incident diabetes mellitus in women with and without HIV infection. In: AIDS. 2018 ; Vol. 32, No. 12. pp. 1643-1650.
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T1 - Abdominal fat depots, insulin resistance, and incident diabetes mellitus in women with and without HIV infection

AU - Glesby, Marshall J.

AU - Hanna, David B.

AU - Hoover, Donald R.

AU - Shi, Qiuhu

AU - Yin, Michael T.

AU - Tien, Phyllis C.

AU - Cohen, Mardge

AU - Anastos, Kathryn

AU - Sharma, Anjali

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Y1 - 2018/1/1

N2 - Objective: The aim of this study was to determine the associations between visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) mass with homeostatic model assessment-insulin resistance (HOMA-IR) and incidence of diabetes mellitus in women with and without HIV infection. Design: Cross-sectional design for associations between abdominal fat and HOMA-IR; longitudinal design for associations between abdominal fat and incident diabetes. Methods: We assessed associations between dual X-ray absorptiometry scan-derived VAT and SAT with HOMA-IR in a subsample from the Women's Interagency HIV Study (n=226 with and n=100 without HIV) using linear regression. We evaluated associations of VAT, SAT and HOMA-IR with incident diabetes mellitus using Cox proportional hazards models. Results: VAT mass was positively associated with log HOMA-IR in fully adjusted linear regression models stratified by HIV serostatus, including adjustment for SAT. During median follow-up of 10.6 years, incidence of diabetes was 1.63 [95% confidence interval (95% CI) 1.15-2.31] and 1.32 [95% CI 0.77-2.28] cases per 100 person-years in women with and without HIV (P=0.52). In a fully adjusted model, baseline VAT (hazard ratio 2.64 per kg; 95% CI 1.14-6.12; P=0.023) and SAT (hazard ratio 1.34 per kg; 95% CI 0.73-2.45; P=0.35) were associated with incident diabetes, but the latter was not statistically significant. Conclusion: VAT mass was independently associated with HOMA-IR in women with and without HIV and was independently associated with future development of diabetes.

AB - Objective: The aim of this study was to determine the associations between visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) mass with homeostatic model assessment-insulin resistance (HOMA-IR) and incidence of diabetes mellitus in women with and without HIV infection. Design: Cross-sectional design for associations between abdominal fat and HOMA-IR; longitudinal design for associations between abdominal fat and incident diabetes. Methods: We assessed associations between dual X-ray absorptiometry scan-derived VAT and SAT with HOMA-IR in a subsample from the Women's Interagency HIV Study (n=226 with and n=100 without HIV) using linear regression. We evaluated associations of VAT, SAT and HOMA-IR with incident diabetes mellitus using Cox proportional hazards models. Results: VAT mass was positively associated with log HOMA-IR in fully adjusted linear regression models stratified by HIV serostatus, including adjustment for SAT. During median follow-up of 10.6 years, incidence of diabetes was 1.63 [95% confidence interval (95% CI) 1.15-2.31] and 1.32 [95% CI 0.77-2.28] cases per 100 person-years in women with and without HIV (P=0.52). In a fully adjusted model, baseline VAT (hazard ratio 2.64 per kg; 95% CI 1.14-6.12; P=0.023) and SAT (hazard ratio 1.34 per kg; 95% CI 0.73-2.45; P=0.35) were associated with incident diabetes, but the latter was not statistically significant. Conclusion: VAT mass was independently associated with HOMA-IR in women with and without HIV and was independently associated with future development of diabetes.

KW - Diabetes mellitus

KW - HIV-1

KW - Insulin resistance

KW - Subcutaneous adipose tissue

KW - Visceral adipose tissue

KW - Women

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