A trial of vitamin a therapy to facilitate ductal closure in premature infants

Chitra Ravishankar, Suhas M. Nafday, Robert S. Green, Steven Kamenir, Richard Lorber, Maria Stacewicz-Sapuntzakis, Nancy D. Bridges, Ian R. Holzman, Bruce D. Gelb

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: To determine whether postnatal vitamin A therapy increased ductal closure rate in premature infants. Study design: This was a prospective, double-blind, placebo-controlled trial. Subjects (n = 40) were recruited on day of life 1. Inclusion criteria were premature neonates weighing 500 to 1500 g with an indwelling umbilical line. Vitamin A was administered intramuscularly on days 1, 3, and 7. Blood vitamin A and retinol binding protein levels were obtained on days 1 and 3. Echocardiography was performed on days 1, 3, 7, and 14. Failure of ductal closure was defined as the presence of a moderate to large patent ductus arteriosus on day 14, indomethacin therapy, or surgical ligation. Results: Comparison between the treatment and placebo groups revealed no differences in gestational age, weight, or oxygenation index. Vitamin A and retinol binding protein levels did not differ between the groups at entry but increased significantly after vitamin A treatment. Failure of ductal closure occurred in 22 of 40 babies without any difference between the groups (12/22 vs 10/18, P = NS). Four infants required surgical ligation, all in the treatment group (P = .04). Clinical outcome did not vary between groups. Conclusion: Postnatal vitamin A therapy did not improve ductal closure rates in premature infants.

Original languageEnglish (US)
Pages (from-to)644-648
Number of pages5
JournalJournal of Pediatrics
Volume143
Issue number5
DOIs
StatePublished - Nov 2003
Externally publishedYes

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Vitamin A
Premature Infants
Vitamins
Retinol-Binding Proteins
Ligation
Therapeutics
Placebos
Umbilicus
Patent Ductus Arteriosus
Indomethacin
Gestational Age
Echocardiography
Newborn Infant
Weights and Measures

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Ravishankar, C., Nafday, S. M., Green, R. S., Kamenir, S., Lorber, R., Stacewicz-Sapuntzakis, M., ... Gelb, B. D. (2003). A trial of vitamin a therapy to facilitate ductal closure in premature infants. Journal of Pediatrics, 143(5), 644-648. https://doi.org/10.1067/S0022-3476(03)00501-8

A trial of vitamin a therapy to facilitate ductal closure in premature infants. / Ravishankar, Chitra; Nafday, Suhas M.; Green, Robert S.; Kamenir, Steven; Lorber, Richard; Stacewicz-Sapuntzakis, Maria; Bridges, Nancy D.; Holzman, Ian R.; Gelb, Bruce D.

In: Journal of Pediatrics, Vol. 143, No. 5, 11.2003, p. 644-648.

Research output: Contribution to journalArticle

Ravishankar, C, Nafday, SM, Green, RS, Kamenir, S, Lorber, R, Stacewicz-Sapuntzakis, M, Bridges, ND, Holzman, IR & Gelb, BD 2003, 'A trial of vitamin a therapy to facilitate ductal closure in premature infants', Journal of Pediatrics, vol. 143, no. 5, pp. 644-648. https://doi.org/10.1067/S0022-3476(03)00501-8
Ravishankar C, Nafday SM, Green RS, Kamenir S, Lorber R, Stacewicz-Sapuntzakis M et al. A trial of vitamin a therapy to facilitate ductal closure in premature infants. Journal of Pediatrics. 2003 Nov;143(5):644-648. https://doi.org/10.1067/S0022-3476(03)00501-8
Ravishankar, Chitra ; Nafday, Suhas M. ; Green, Robert S. ; Kamenir, Steven ; Lorber, Richard ; Stacewicz-Sapuntzakis, Maria ; Bridges, Nancy D. ; Holzman, Ian R. ; Gelb, Bruce D. / A trial of vitamin a therapy to facilitate ductal closure in premature infants. In: Journal of Pediatrics. 2003 ; Vol. 143, No. 5. pp. 644-648.
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