A treatment trial of vitamin d supplementation in breast-fed infants: Universal supplementation is not necessary for rickets preventio in southern louisiana

Tulasi Ponnapakkam, Elease Bradford, Robert Gensure

Research output: Contribution to journalArticle

12 Scopus citations


This study was conducted to determine if vitamin D supplementation is required to prevent rickets in breast-fed infants. Breast-feeding rates are increasing, and there are concerns about whether the vitamin D content of breast milk is sufficient. There are a few treatment trials of vitamin D supplementation in breast-fed infants; these were conducted in northern climates. The authors therefore performed a prospective clinical trial comparing vitamin D supplementation with placebo as control in southern Louisiana. Blood samples and questionnaires were collected at birth, 2, 4, and 6 months of age. There were no cases of rickets observed, and no differences in alkaline phosphatas levels between groups. Thus, there was no evidence that vitamin D supplementation reduced rickets risk in theauthors' study population. This suggests that the current recommendations for universal vitamin D supplementationof breast-fed infants throughout the United States may need to be revised.

Original languageEnglish (US)
Pages (from-to)1053-1060
Number of pages8
JournalClinical Pediatrics
Issue number11
Publication statusPublished - Nov 1 2010



  • American Academy of Pediatrics (AAP)
  • Rickets
  • Vitamin D supplementation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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