A treatment algorithm to identify therapeutic approaches for leg ulcers in patients with sickle cell disease

Igor A. Altman, Raymond E. Kleinfelder, John G. Quigley, William J. Ennis, Caterina P. Minniti

Research output: Contribution to journalArticle

7 Scopus citations


Sickle cell leg ulcers (SCLUs) are a common complication of sickle cell disease (SCD). Patients who develop ulcers appear to have a more severe haemolysis-associated vasculopathy than individuals who do not develop them, and manifest other complications such as priapism and pulmonary hypertension. SCLUs are slow to heal and often recur, affecting both the emotional and physical well-being of patients. Here we summarise what is known about the pathophysiology of SCLUs, describe available treatment options and propose a treatment algorithm.

Original languageEnglish (US)
JournalInternational Wound Journal
StateAccepted/In press - Jan 1 2015



  • Pathophysiology
  • Sickle cell leg ulcers
  • Sickle cell wounds
  • Treatment algorithm

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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