A treatment algorithm to identify therapeutic approaches for leg ulcers in patients with sickle cell disease

Igor A. Altman, Raymond E. Kleinfelder, John G. Quigley, William J. Ennis, Caterina P. Minniti

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Sickle cell leg ulcers (SCLUs) are a common complication of sickle cell disease (SCD). Patients who develop ulcers appear to have a more severe haemolysis-associated vasculopathy than individuals who do not develop them, and manifest other complications such as priapism and pulmonary hypertension. SCLUs are slow to heal and often recur, affecting both the emotional and physical well-being of patients. Here we summarise what is known about the pathophysiology of SCLUs, describe available treatment options and propose a treatment algorithm.

Original languageEnglish (US)
JournalInternational Wound Journal
DOIs
StateAccepted/In press - 2015

Fingerprint

Leg Ulcer
Sickle Cell Anemia
Priapism
Hemolysis
Pulmonary Hypertension
Ulcer
Therapeutics

Keywords

  • Pathophysiology
  • Sickle cell leg ulcers
  • Sickle cell wounds
  • Treatment algorithm

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Cite this

A treatment algorithm to identify therapeutic approaches for leg ulcers in patients with sickle cell disease. / Altman, Igor A.; Kleinfelder, Raymond E.; Quigley, John G.; Ennis, William J.; Minniti, Caterina P.

In: International Wound Journal, 2015.

Research output: Contribution to journalArticle

@article{e370fd71c85840f7b1cf1d03c85b7877,
title = "A treatment algorithm to identify therapeutic approaches for leg ulcers in patients with sickle cell disease",
abstract = "Sickle cell leg ulcers (SCLUs) are a common complication of sickle cell disease (SCD). Patients who develop ulcers appear to have a more severe haemolysis-associated vasculopathy than individuals who do not develop them, and manifest other complications such as priapism and pulmonary hypertension. SCLUs are slow to heal and often recur, affecting both the emotional and physical well-being of patients. Here we summarise what is known about the pathophysiology of SCLUs, describe available treatment options and propose a treatment algorithm.",
keywords = "Pathophysiology, Sickle cell leg ulcers, Sickle cell wounds, Treatment algorithm",
author = "Altman, {Igor A.} and Kleinfelder, {Raymond E.} and Quigley, {John G.} and Ennis, {William J.} and Minniti, {Caterina P.}",
year = "2015",
doi = "10.1111/iwj.12522",
language = "English (US)",
journal = "International Wound Journal",
issn = "1742-4801",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - A treatment algorithm to identify therapeutic approaches for leg ulcers in patients with sickle cell disease

AU - Altman, Igor A.

AU - Kleinfelder, Raymond E.

AU - Quigley, John G.

AU - Ennis, William J.

AU - Minniti, Caterina P.

PY - 2015

Y1 - 2015

N2 - Sickle cell leg ulcers (SCLUs) are a common complication of sickle cell disease (SCD). Patients who develop ulcers appear to have a more severe haemolysis-associated vasculopathy than individuals who do not develop them, and manifest other complications such as priapism and pulmonary hypertension. SCLUs are slow to heal and often recur, affecting both the emotional and physical well-being of patients. Here we summarise what is known about the pathophysiology of SCLUs, describe available treatment options and propose a treatment algorithm.

AB - Sickle cell leg ulcers (SCLUs) are a common complication of sickle cell disease (SCD). Patients who develop ulcers appear to have a more severe haemolysis-associated vasculopathy than individuals who do not develop them, and manifest other complications such as priapism and pulmonary hypertension. SCLUs are slow to heal and often recur, affecting both the emotional and physical well-being of patients. Here we summarise what is known about the pathophysiology of SCLUs, describe available treatment options and propose a treatment algorithm.

KW - Pathophysiology

KW - Sickle cell leg ulcers

KW - Sickle cell wounds

KW - Treatment algorithm

UR - http://www.scopus.com/inward/record.url?scp=84955269422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955269422&partnerID=8YFLogxK

U2 - 10.1111/iwj.12522

DO - 10.1111/iwj.12522

M3 - Article

JO - International Wound Journal

JF - International Wound Journal

SN - 1742-4801

ER -