A transition in brain state during propofol-induced unconsciousness

Eran A. Mukamel, Elvira Pirondini, Behtash Babadi, Kin Foon Kevin Wong, Eric T. Pierce, P. Grace Harrell, John L. Walsh, Andres F. Salazar-Gomez, Sydney S. Cash, Emad N. Eskandar, Veronica S. Weiner, Emery N. Brown, Patrick L. Purdon

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Rhythmic oscillations shape cortical dynamics during active behavior, sleep, and general anesthesia. Cross-frequency phase-amplitude coupling is a prominent feature of cortical oscillations, but its role in organizing conscious and unconscious brain states is poorly understood. Using high-density EEG and intracranial electrocorticography during gradual induction of propofol general anesthesia in humans, we discovered a rapid drug-induced transition between distinct states with opposite phase-amplitude coupling and different cortical source distributions. One state occurs during unconsciousness and may be similar to sleep slow oscillations. A second state occurs at the loss or recovery of consciousness and resembles an enhanced slow cortical potential. These results provide objective electrophysiological landmarks of distinct unconscious brain states, and could be used to help improve EEG-based monitoring for general anesthesia.

Original languageEnglish (US)
Pages (from-to)839-845
Number of pages7
JournalJournal of Neuroscience
Volume34
Issue number3
DOIs
StatePublished - Jan 20 2014
Externally publishedYes

Fingerprint

Unconsciousness
Propofol
General Anesthesia
Sleep
Brain
Consciousness
Electroencephalography
Pharmaceutical Preparations
Electrocorticography

Keywords

  • α Rhythm
  • Anesthesia
  • Cross-frequency coupling
  • Propofol
  • Slow oscillation
  • Unconsciousness

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mukamel, E. A., Pirondini, E., Babadi, B., Wong, K. F. K., Pierce, E. T., Harrell, P. G., ... Purdon, P. L. (2014). A transition in brain state during propofol-induced unconsciousness. Journal of Neuroscience, 34(3), 839-845. https://doi.org/10.1523/JNEUROSCI.5813-12.2014

A transition in brain state during propofol-induced unconsciousness. / Mukamel, Eran A.; Pirondini, Elvira; Babadi, Behtash; Wong, Kin Foon Kevin; Pierce, Eric T.; Harrell, P. Grace; Walsh, John L.; Salazar-Gomez, Andres F.; Cash, Sydney S.; Eskandar, Emad N.; Weiner, Veronica S.; Brown, Emery N.; Purdon, Patrick L.

In: Journal of Neuroscience, Vol. 34, No. 3, 20.01.2014, p. 839-845.

Research output: Contribution to journalArticle

Mukamel, EA, Pirondini, E, Babadi, B, Wong, KFK, Pierce, ET, Harrell, PG, Walsh, JL, Salazar-Gomez, AF, Cash, SS, Eskandar, EN, Weiner, VS, Brown, EN & Purdon, PL 2014, 'A transition in brain state during propofol-induced unconsciousness', Journal of Neuroscience, vol. 34, no. 3, pp. 839-845. https://doi.org/10.1523/JNEUROSCI.5813-12.2014
Mukamel EA, Pirondini E, Babadi B, Wong KFK, Pierce ET, Harrell PG et al. A transition in brain state during propofol-induced unconsciousness. Journal of Neuroscience. 2014 Jan 20;34(3):839-845. https://doi.org/10.1523/JNEUROSCI.5813-12.2014
Mukamel, Eran A. ; Pirondini, Elvira ; Babadi, Behtash ; Wong, Kin Foon Kevin ; Pierce, Eric T. ; Harrell, P. Grace ; Walsh, John L. ; Salazar-Gomez, Andres F. ; Cash, Sydney S. ; Eskandar, Emad N. ; Weiner, Veronica S. ; Brown, Emery N. ; Purdon, Patrick L. / A transition in brain state during propofol-induced unconsciousness. In: Journal of Neuroscience. 2014 ; Vol. 34, No. 3. pp. 839-845.
@article{3f0ece793fd94b3c857875527d54bbe3,
title = "A transition in brain state during propofol-induced unconsciousness",
abstract = "Rhythmic oscillations shape cortical dynamics during active behavior, sleep, and general anesthesia. Cross-frequency phase-amplitude coupling is a prominent feature of cortical oscillations, but its role in organizing conscious and unconscious brain states is poorly understood. Using high-density EEG and intracranial electrocorticography during gradual induction of propofol general anesthesia in humans, we discovered a rapid drug-induced transition between distinct states with opposite phase-amplitude coupling and different cortical source distributions. One state occurs during unconsciousness and may be similar to sleep slow oscillations. A second state occurs at the loss or recovery of consciousness and resembles an enhanced slow cortical potential. These results provide objective electrophysiological landmarks of distinct unconscious brain states, and could be used to help improve EEG-based monitoring for general anesthesia.",
keywords = "α Rhythm, Anesthesia, Cross-frequency coupling, Propofol, Slow oscillation, Unconsciousness",
author = "Mukamel, {Eran A.} and Elvira Pirondini and Behtash Babadi and Wong, {Kin Foon Kevin} and Pierce, {Eric T.} and Harrell, {P. Grace} and Walsh, {John L.} and Salazar-Gomez, {Andres F.} and Cash, {Sydney S.} and Eskandar, {Emad N.} and Weiner, {Veronica S.} and Brown, {Emery N.} and Purdon, {Patrick L.}",
year = "2014",
month = "1",
day = "20",
doi = "10.1523/JNEUROSCI.5813-12.2014",
language = "English (US)",
volume = "34",
pages = "839--845",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "3",

}

TY - JOUR

T1 - A transition in brain state during propofol-induced unconsciousness

AU - Mukamel, Eran A.

AU - Pirondini, Elvira

AU - Babadi, Behtash

AU - Wong, Kin Foon Kevin

AU - Pierce, Eric T.

AU - Harrell, P. Grace

AU - Walsh, John L.

AU - Salazar-Gomez, Andres F.

AU - Cash, Sydney S.

AU - Eskandar, Emad N.

AU - Weiner, Veronica S.

AU - Brown, Emery N.

AU - Purdon, Patrick L.

PY - 2014/1/20

Y1 - 2014/1/20

N2 - Rhythmic oscillations shape cortical dynamics during active behavior, sleep, and general anesthesia. Cross-frequency phase-amplitude coupling is a prominent feature of cortical oscillations, but its role in organizing conscious and unconscious brain states is poorly understood. Using high-density EEG and intracranial electrocorticography during gradual induction of propofol general anesthesia in humans, we discovered a rapid drug-induced transition between distinct states with opposite phase-amplitude coupling and different cortical source distributions. One state occurs during unconsciousness and may be similar to sleep slow oscillations. A second state occurs at the loss or recovery of consciousness and resembles an enhanced slow cortical potential. These results provide objective electrophysiological landmarks of distinct unconscious brain states, and could be used to help improve EEG-based monitoring for general anesthesia.

AB - Rhythmic oscillations shape cortical dynamics during active behavior, sleep, and general anesthesia. Cross-frequency phase-amplitude coupling is a prominent feature of cortical oscillations, but its role in organizing conscious and unconscious brain states is poorly understood. Using high-density EEG and intracranial electrocorticography during gradual induction of propofol general anesthesia in humans, we discovered a rapid drug-induced transition between distinct states with opposite phase-amplitude coupling and different cortical source distributions. One state occurs during unconsciousness and may be similar to sleep slow oscillations. A second state occurs at the loss or recovery of consciousness and resembles an enhanced slow cortical potential. These results provide objective electrophysiological landmarks of distinct unconscious brain states, and could be used to help improve EEG-based monitoring for general anesthesia.

KW - α Rhythm

KW - Anesthesia

KW - Cross-frequency coupling

KW - Propofol

KW - Slow oscillation

KW - Unconsciousness

UR - http://www.scopus.com/inward/record.url?scp=84892382659&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892382659&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.5813-12.2014

DO - 10.1523/JNEUROSCI.5813-12.2014

M3 - Article

VL - 34

SP - 839

EP - 845

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 3

ER -