A teenage boy with hypocalcemia after radioablation for Graves' disease

Oksana Lazareva, Aristotle Panayiotopoulos, Irina Kazachkova, Elka Jacobson-Dickman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Excessive thyroid hormone production, as seen in Graves' disease, stimulates osteoblast-mediated bone turnover in favor of bone resorption. Acute reversal of bone resorption can lead to hungry bone syndrome (HBS), a state of rapid calcium deposition into newly synthesized osteoid resulting in hypocalcemia. Hypocalcemia due to subsequent functional or relative hypoparathyroidism is a recognized complication of therapy for Graves' disease. HBS is most recognized as an outcome of rapid correction of vitamin D deficiency or of acute hypoparathyroidism in cases of parathyroid gland function disruption after surgical removal of the thyroid. We report the case of an adolescent boy with Graves' disease who presented with hypocalcemia after radioactive iodine (131I) therapy due to HBS. Our report highlights the risk of HBS and severe hypocalcemia following treatment for Graves' disease in pediatric patients and also underscores the importance of pretreatment assessment and intervention for coexistent vitamin D deficiency.

Original languageEnglish (US)
Pages (from-to)379-382
Number of pages4
JournalJournal of Pediatric Endocrinology and Metabolism
Volume27
Issue number3-4
DOIs
StatePublished - Mar 1 2014

Fingerprint

Hypocalcemia
Graves Disease
Bone and Bones
Hypoparathyroidism
Vitamin D Deficiency
Bone Resorption
Parathyroid Glands
Bone Remodeling
Osteoblasts
Thyroid Hormones
Iodine
Thyroid Gland
Therapeutics
Pediatrics
Calcium

Keywords

  • Graves' disease
  • hungry bone syndrome
  • hypocalcemia

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

A teenage boy with hypocalcemia after radioablation for Graves' disease. / Lazareva, Oksana; Panayiotopoulos, Aristotle; Kazachkova, Irina; Jacobson-Dickman, Elka.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 27, No. 3-4, 01.03.2014, p. 379-382.

Research output: Contribution to journalArticle

Lazareva, O, Panayiotopoulos, A, Kazachkova, I & Jacobson-Dickman, E 2014, 'A teenage boy with hypocalcemia after radioablation for Graves' disease', Journal of Pediatric Endocrinology and Metabolism, vol. 27, no. 3-4, pp. 379-382. https://doi.org/10.1515/jpem-2013-0322
Lazareva, Oksana ; Panayiotopoulos, Aristotle ; Kazachkova, Irina ; Jacobson-Dickman, Elka. / A teenage boy with hypocalcemia after radioablation for Graves' disease. In: Journal of Pediatric Endocrinology and Metabolism. 2014 ; Vol. 27, No. 3-4. pp. 379-382.
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