A TagSNP in SIRT1 gene confers susceptibility to myocardial infarction in a Chinese Han population

Jie Cheng, Miook Cho, Jin Ming Cen, Meng Yun Cai, Shun Xu, Ze Wei Ma, Xinguang Liu, Xi Li Yang, Can Chen, Yousin Suh, Xing Dong Xiong

Research output: Contribution to journalArticle

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Abstract

SIRT1 exerts protective effects against endothelial cells dysfunction, inflammation and atherosclerosis, indicating an important role on myocardial infarction (MI) pathogenesis. Nonetheless, the effects of SIRT1 variants on MI risk remain poorly understood. Here we aimed to investigate the influence of SIRT1 polymorphisms on individual susceptibility to MI. Genotyping of three tagSNPs (rs7069102, rs3818292 and rs4746720) in SIRT1 gene was performed in a Chinese Han population, consisting of 287 MI cases and 654 control subjects. In a logistic regression analysis, we found that G allele of rs7069102 had increased MI risk with odds ratio (OR) of 1.57 [95% confidence interval (CI) = 1.15-2.16, Bonferroni corrected P (Pc) = 0.015] after adjustment for conventional risk factors compared to C allele. Similarly, the combined CG/GG genotypes was associated with the increased MI risk (OR = 1.64, 95% CI = 1.14-2.35, Pc = 0.021) compared to the CC genotype. Further stratified analysis revealed a more significant association with MI risk among younger subjects (≤ 55 years old). Consistent with these results, the haplotype rs7069102G-rs3818292A-rs4746720T containing the rs7069102 G allele was also associated with the increased MI risk (OR = 1.41, 95% CI = 1.09-1.84, Pc = 0.040). However, we did not detect any association of rs3818292 and rs4746720 with MI risk. Our study provides the first evidence that the tagSNP rs7069102 and haplotype rs7069102G-rs3818292A-rs4746720T in SIRT1 gene confer susceptibility to MI in the Chinese Han population.

Original languageEnglish (US)
Article numbere0115339
JournalPLoS One
Volume10
Issue number2
DOIs
StatePublished - Feb 23 2015

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myocardial infarction
Genes
Myocardial Infarction
Population
genes
Odds Ratio
odds ratio
confidence interval
Alleles
Confidence Intervals
alleles
Haplotypes
haplotypes
Endothelial cells
Genotype
Polymorphism
Regression analysis
Logistics
genotype
atherosclerosis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Cheng, J., Cho, M., Cen, J. M., Cai, M. Y., Xu, S., Ma, Z. W., ... Xiong, X. D. (2015). A TagSNP in SIRT1 gene confers susceptibility to myocardial infarction in a Chinese Han population. PLoS One, 10(2), [e0115339]. https://doi.org/10.1371/journal.pone.0115339

A TagSNP in SIRT1 gene confers susceptibility to myocardial infarction in a Chinese Han population. / Cheng, Jie; Cho, Miook; Cen, Jin Ming; Cai, Meng Yun; Xu, Shun; Ma, Ze Wei; Liu, Xinguang; Yang, Xi Li; Chen, Can; Suh, Yousin; Xiong, Xing Dong.

In: PLoS One, Vol. 10, No. 2, e0115339, 23.02.2015.

Research output: Contribution to journalArticle

Cheng, J, Cho, M, Cen, JM, Cai, MY, Xu, S, Ma, ZW, Liu, X, Yang, XL, Chen, C, Suh, Y & Xiong, XD 2015, 'A TagSNP in SIRT1 gene confers susceptibility to myocardial infarction in a Chinese Han population', PLoS One, vol. 10, no. 2, e0115339. https://doi.org/10.1371/journal.pone.0115339
Cheng, Jie ; Cho, Miook ; Cen, Jin Ming ; Cai, Meng Yun ; Xu, Shun ; Ma, Ze Wei ; Liu, Xinguang ; Yang, Xi Li ; Chen, Can ; Suh, Yousin ; Xiong, Xing Dong. / A TagSNP in SIRT1 gene confers susceptibility to myocardial infarction in a Chinese Han population. In: PLoS One. 2015 ; Vol. 10, No. 2.
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AU - Ma, Ze Wei

AU - Liu, Xinguang

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AB - SIRT1 exerts protective effects against endothelial cells dysfunction, inflammation and atherosclerosis, indicating an important role on myocardial infarction (MI) pathogenesis. Nonetheless, the effects of SIRT1 variants on MI risk remain poorly understood. Here we aimed to investigate the influence of SIRT1 polymorphisms on individual susceptibility to MI. Genotyping of three tagSNPs (rs7069102, rs3818292 and rs4746720) in SIRT1 gene was performed in a Chinese Han population, consisting of 287 MI cases and 654 control subjects. In a logistic regression analysis, we found that G allele of rs7069102 had increased MI risk with odds ratio (OR) of 1.57 [95% confidence interval (CI) = 1.15-2.16, Bonferroni corrected P (Pc) = 0.015] after adjustment for conventional risk factors compared to C allele. Similarly, the combined CG/GG genotypes was associated with the increased MI risk (OR = 1.64, 95% CI = 1.14-2.35, Pc = 0.021) compared to the CC genotype. Further stratified analysis revealed a more significant association with MI risk among younger subjects (≤ 55 years old). Consistent with these results, the haplotype rs7069102G-rs3818292A-rs4746720T containing the rs7069102 G allele was also associated with the increased MI risk (OR = 1.41, 95% CI = 1.09-1.84, Pc = 0.040). However, we did not detect any association of rs3818292 and rs4746720 with MI risk. Our study provides the first evidence that the tagSNP rs7069102 and haplotype rs7069102G-rs3818292A-rs4746720T in SIRT1 gene confer susceptibility to MI in the Chinese Han population.

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