TY - JOUR
T1 - A systematic, multidisciplinary approach to address the reproductive needs of HIV-seropositive women
AU - Douglas, Nataki C.
AU - Wang, Jeff G.
AU - Yu, Bo
AU - Gaddipati, Sreedhar
AU - Guarnaccia, Michael M.
AU - Sauer, Mark V.
PY - 2009/8
Y1 - 2009/8
N2 - Nearly 130,000 American women are human immunodeficiency virus (HIV) seropositive. The present study sought to establish a comprehensive programme to address their fertility needs in order to minimize infectious, medical and reproductive risks to prospective patients. Forty women, aged 27-42 years, were evaluated. HIV was diagnosed 7.2 ± 0.7 years prior to their seeking care, and most women (n = 38) were on highly active antiretroviral therapy. Their prenatal CD4 counts were 712.2 ± 56 cells/mm3 (range 327-1881) and HIV-1 concentrations were undetectable in all cases prior to initiating treatment. HIV-seropositive women were statistically identical to their age-matched HIV-seronegative counterparts with respect to the IVF clinical outcome parameters measured. Throughout the pregnancies, maternal HIV-1 RNA concentrations remained undetectable and CD4 counts were stable. AU infants, tested at birth and at 3 and 6 months of age, remained HIV negative. This is the first report of an institutional paradigm in the USA dedicated to evaluate and treat HIV-seropositive women. Using a multidisciplinary approach to care, HIV-seropositive women may be successfully managed in a programme of assisted reproduction.
AB - Nearly 130,000 American women are human immunodeficiency virus (HIV) seropositive. The present study sought to establish a comprehensive programme to address their fertility needs in order to minimize infectious, medical and reproductive risks to prospective patients. Forty women, aged 27-42 years, were evaluated. HIV was diagnosed 7.2 ± 0.7 years prior to their seeking care, and most women (n = 38) were on highly active antiretroviral therapy. Their prenatal CD4 counts were 712.2 ± 56 cells/mm3 (range 327-1881) and HIV-1 concentrations were undetectable in all cases prior to initiating treatment. HIV-seropositive women were statistically identical to their age-matched HIV-seronegative counterparts with respect to the IVF clinical outcome parameters measured. Throughout the pregnancies, maternal HIV-1 RNA concentrations remained undetectable and CD4 counts were stable. AU infants, tested at birth and at 3 and 6 months of age, remained HIV negative. This is the first report of an institutional paradigm in the USA dedicated to evaluate and treat HIV-seropositive women. Using a multidisciplinary approach to care, HIV-seropositive women may be successfully managed in a programme of assisted reproduction.
KW - Fertility
KW - HIV-seropositive women
KW - IVF
UR - http://www.scopus.com/inward/record.url?scp=69249139939&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69249139939&partnerID=8YFLogxK
U2 - 10.1016/S1472-6483(10)60082-X
DO - 10.1016/S1472-6483(10)60082-X
M3 - Article
C2 - 19712564
AN - SCOPUS:69249139939
SN - 1472-6483
VL - 19
SP - 257
EP - 263
JO - Reproductive BioMedicine Online
JF - Reproductive BioMedicine Online
IS - 2
ER -