A subset of Notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex

Petros Ligoxygakis, Sung Yun Yu, Christos Delidakis, Nicholas E. Baker

Research output: Contribution to journalArticlepeer-review

105 Scopus citations

Abstract

The Notch signalling pathway is involved in many processes where cell fate is decided. Previous work showed that Notch is required at successive steps during R8 specification in the Drosophila eye. Initially, Notch enhances atonal expression and promotes atonal function. After atonal autoregulation has been established, Notch signalling represses atonal expression during lateral specification, In this paper we investigate which known components of the Notch pathway are involved in each signalling process. Using clonal analysis we show that a ligand of Notch, Delta, is required along with Notch for both proneural enhancement and lateral specification, while the downstream components Suppressor-of-Hairless and Enhancer-of-Split are involved only in lateral specification. Our data point to a distinct signal transduction pathway during proneural enhancement by Notch. Using misexpression experiments we also show that particular Enhancer-of-split bHLH genes can differ greatly in their contribution to lateral specification.

Original languageEnglish (US)
Pages (from-to)2893-2900
Number of pages8
JournalDevelopment
Volume125
Issue number15
StatePublished - Aug 1 1998

Keywords

  • Atonal
  • Drosophila eye
  • Enhancer of split
  • Notch
  • Suppressor of hairless

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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