A stretch-sensitive Cl- channel in human corpus cavernosal myocytes

S. F. Fan, G. J. Christ, A. Melman, P. R. Brink

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

With the patch clamp method we demonstrate a stretch-sensitive Cl- currents as well as stretch-sensitive Cl- channels in a small group (≃ 5%, n = 117) of cultured human corpus cavernosal muscle cells. The current and the channel activities had the following characteristics: (1) Their equilibrium potentials changed with extracellular Cl- concentration close to that predicted by Nernst equation provided that the relevant channels had high permeability to Cl- but low permeability to acetate ions; (2) They were blocked by mM concentrations of Zn2+; (3) The i-v relation of single channel current was almost linear for holding potentials varied from -70 to +60 mV; and (4) The channels had unitary conductances of ≃ 140-170 pS.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalInternational journal of impotence research
Volume11
Issue number1
DOIs
StatePublished - Feb 1999

Keywords

  • Corpus cavernosal myocyte
  • Stretch-sensitive Cl channel

ASJC Scopus subject areas

  • Urology

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