Abstract
With the patch clamp method we demonstrate a stretch-sensitive Cl- currents as well as stretch-sensitive Cl- channels in a small group (≃ 5%, n = 117) of cultured human corpus cavernosal muscle cells. The current and the channel activities had the following characteristics: (1) Their equilibrium potentials changed with extracellular Cl- concentration close to that predicted by Nernst equation provided that the relevant channels had high permeability to Cl- but low permeability to acetate ions; (2) They were blocked by mM concentrations of Zn2+; (3) The i-v relation of single channel current was almost linear for holding potentials varied from -70 to +60 mV; and (4) The channels had unitary conductances of ≃ 140-170 pS.
Original language | English (US) |
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Pages (from-to) | 1-7 |
Number of pages | 7 |
Journal | International journal of impotence research |
Volume | 11 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1999 |
Keywords
- Corpus cavernosal myocyte
- Stretch-sensitive Cl channel
ASJC Scopus subject areas
- Urology