A stain upon the silence

Genes escaping X inactivation

Carolyn J. Brown, John M. Greally

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

X-chromosome inactivation is a remarkable epigenetic event in mammalian females that results in the transcriptional silencing of one of the pair of X chromosomes. However, not all X-linked genes are subject to inactivation, and in humans, the proportion of genes on the X chromosome that escapes inactivation is more than 15%. Here we examine the causes and consequences of failure to silence the entire X chromosome. We discuss the impact of the evolutionary history of the X (and Y) chromosome, and the bioinformatic approaches that promise to provide new insights into the genomic architecture of genes or regions that escape X-chromosome inactivation.

Original languageEnglish (US)
Pages (from-to)432-438
Number of pages7
JournalTrends in Genetics
Volume19
Issue number8
DOIs
StatePublished - Aug 1 2003

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X Chromosome Inactivation
X Chromosome
Coloring Agents
Genes
X-Linked Genes
Y Chromosome
Computational Biology
Epigenomics
History

ASJC Scopus subject areas

  • Genetics

Cite this

A stain upon the silence : Genes escaping X inactivation. / Brown, Carolyn J.; Greally, John M.

In: Trends in Genetics, Vol. 19, No. 8, 01.08.2003, p. 432-438.

Research output: Contribution to journalArticle

Brown, Carolyn J. ; Greally, John M. / A stain upon the silence : Genes escaping X inactivation. In: Trends in Genetics. 2003 ; Vol. 19, No. 8. pp. 432-438.
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