A single intravenous injection of doxorubicin (Adriamycin®) induces sensory neuronopathy in rats

E. S. Cho, P. S. Spencer, B. S. Jortner, H. H. Schaumburg

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The anthracycline compound doxorubicin, used in the treatment of malignant tumors, produced a sensory neuronopathy in experimental animals. Rats which had received a single intravenous dose of 10 mg/kg developed a progressive hind-limb ataxia without apparent weakness 11 or 12 days after treatment. Examination revealed neuronal degeneration in the ganglia of the peripheral nervous system. Nuclear changes appearing as early as 3 hours post-injection wer followed by cytoplasmic degeneration visible by 9 days. At least one half of the normal population of neurons was lost by day 34. Secondary degeneration of sensory nerve fibers in peripheral nerves and dorsal columns of spinal cord was apparent. These neuronal changes may be explained by 1) the known selective permeability of blood vessels in the peripheral ganglia, 2) intercalation of doxorubicin nucleic acids and 3) resultant permanent disruption of nucleic acid metabolism in neurons.

Original languageEnglish (US)
Pages (from-to)583-591
Number of pages9
JournalNeuroToxicology
Volume1
Issue number3
StatePublished - 1980
Externally publishedYes

Fingerprint

Intravenous Injections
Ganglia
Doxorubicin
Nucleic Acids
Neurons
Rats
Anthracyclines
Peripheral Nervous System
Blood vessels
Neurology
Ataxia
Intercalation
Peripheral Nerves
Nerve Fibers
Metabolism
Blood Vessels
Tumors
Permeability
Spinal Cord
Animals

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience
  • Toxicology

Cite this

Cho, E. S., Spencer, P. S., Jortner, B. S., & Schaumburg, H. H. (1980). A single intravenous injection of doxorubicin (Adriamycin®) induces sensory neuronopathy in rats. NeuroToxicology, 1(3), 583-591.

A single intravenous injection of doxorubicin (Adriamycin®) induces sensory neuronopathy in rats. / Cho, E. S.; Spencer, P. S.; Jortner, B. S.; Schaumburg, H. H.

In: NeuroToxicology, Vol. 1, No. 3, 1980, p. 583-591.

Research output: Contribution to journalArticle

Cho, ES, Spencer, PS, Jortner, BS & Schaumburg, HH 1980, 'A single intravenous injection of doxorubicin (Adriamycin®) induces sensory neuronopathy in rats', NeuroToxicology, vol. 1, no. 3, pp. 583-591.
Cho, E. S. ; Spencer, P. S. ; Jortner, B. S. ; Schaumburg, H. H. / A single intravenous injection of doxorubicin (Adriamycin®) induces sensory neuronopathy in rats. In: NeuroToxicology. 1980 ; Vol. 1, No. 3. pp. 583-591.
@article{78a4e0c068aa472997af7844288d1f9c,
title = "A single intravenous injection of doxorubicin (Adriamycin{\circledR}) induces sensory neuronopathy in rats",
abstract = "The anthracycline compound doxorubicin, used in the treatment of malignant tumors, produced a sensory neuronopathy in experimental animals. Rats which had received a single intravenous dose of 10 mg/kg developed a progressive hind-limb ataxia without apparent weakness 11 or 12 days after treatment. Examination revealed neuronal degeneration in the ganglia of the peripheral nervous system. Nuclear changes appearing as early as 3 hours post-injection wer followed by cytoplasmic degeneration visible by 9 days. At least one half of the normal population of neurons was lost by day 34. Secondary degeneration of sensory nerve fibers in peripheral nerves and dorsal columns of spinal cord was apparent. These neuronal changes may be explained by 1) the known selective permeability of blood vessels in the peripheral ganglia, 2) intercalation of doxorubicin nucleic acids and 3) resultant permanent disruption of nucleic acid metabolism in neurons.",
author = "Cho, {E. S.} and Spencer, {P. S.} and Jortner, {B. S.} and Schaumburg, {H. H.}",
year = "1980",
language = "English (US)",
volume = "1",
pages = "583--591",
journal = "NeuroToxicology",
issn = "0161-813X",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - A single intravenous injection of doxorubicin (Adriamycin®) induces sensory neuronopathy in rats

AU - Cho, E. S.

AU - Spencer, P. S.

AU - Jortner, B. S.

AU - Schaumburg, H. H.

PY - 1980

Y1 - 1980

N2 - The anthracycline compound doxorubicin, used in the treatment of malignant tumors, produced a sensory neuronopathy in experimental animals. Rats which had received a single intravenous dose of 10 mg/kg developed a progressive hind-limb ataxia without apparent weakness 11 or 12 days after treatment. Examination revealed neuronal degeneration in the ganglia of the peripheral nervous system. Nuclear changes appearing as early as 3 hours post-injection wer followed by cytoplasmic degeneration visible by 9 days. At least one half of the normal population of neurons was lost by day 34. Secondary degeneration of sensory nerve fibers in peripheral nerves and dorsal columns of spinal cord was apparent. These neuronal changes may be explained by 1) the known selective permeability of blood vessels in the peripheral ganglia, 2) intercalation of doxorubicin nucleic acids and 3) resultant permanent disruption of nucleic acid metabolism in neurons.

AB - The anthracycline compound doxorubicin, used in the treatment of malignant tumors, produced a sensory neuronopathy in experimental animals. Rats which had received a single intravenous dose of 10 mg/kg developed a progressive hind-limb ataxia without apparent weakness 11 or 12 days after treatment. Examination revealed neuronal degeneration in the ganglia of the peripheral nervous system. Nuclear changes appearing as early as 3 hours post-injection wer followed by cytoplasmic degeneration visible by 9 days. At least one half of the normal population of neurons was lost by day 34. Secondary degeneration of sensory nerve fibers in peripheral nerves and dorsal columns of spinal cord was apparent. These neuronal changes may be explained by 1) the known selective permeability of blood vessels in the peripheral ganglia, 2) intercalation of doxorubicin nucleic acids and 3) resultant permanent disruption of nucleic acid metabolism in neurons.

UR - http://www.scopus.com/inward/record.url?scp=0018901338&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018901338&partnerID=8YFLogxK

M3 - Article

VL - 1

SP - 583

EP - 591

JO - NeuroToxicology

JF - NeuroToxicology

SN - 0161-813X

IS - 3

ER -