A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity

Susana Mato, Vivien Chevaleyre, David Robbe, Angel Pazos, Pablo E. Castillo, Olivier J. Manzoni

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Δ9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and hippocampus in vitro. This effect is reversible within 3 days and is associated with a transient modification in the functional properties of cannabinoid receptors.

Original languageEnglish (US)
Pages (from-to)585-586
Number of pages2
JournalNature Neuroscience
Volume7
Issue number6
DOIs
StatePublished - Jun 2004

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Endocannabinoids
Neuronal Plasticity
Cannabinoids
Cannabinoid Receptors
Dronabinol
Nucleus Accumbens
Reward
Hippocampus
Learning
Brain
In Vitro Techniques

ASJC Scopus subject areas

  • Neuroscience(all)

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A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity. / Mato, Susana; Chevaleyre, Vivien; Robbe, David; Pazos, Angel; Castillo, Pablo E.; Manzoni, Olivier J.

In: Nature Neuroscience, Vol. 7, No. 6, 06.2004, p. 585-586.

Research output: Contribution to journalArticle

Mato, Susana ; Chevaleyre, Vivien ; Robbe, David ; Pazos, Angel ; Castillo, Pablo E. ; Manzoni, Olivier J. / A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity. In: Nature Neuroscience. 2004 ; Vol. 7, No. 6. pp. 585-586.
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