A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity

Susana Mato, Vivien Chevaleyre, David Robbe, Angel Pazos, Pablo E. Castillo, Olivier J. Manzoni

Research output: Contribution to journalArticle

162 Scopus citations


Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Δ9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and hippocampus in vitro. This effect is reversible within 3 days and is associated with a transient modification in the functional properties of cannabinoid receptors.

Original languageEnglish (US)
Pages (from-to)585-586
Number of pages2
JournalNature Neuroscience
Issue number6
StatePublished - Jun 1 2004


ASJC Scopus subject areas

  • Neuroscience(all)

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