A seroepidemiologic study of HPV infection and incident cervical squamous intraepithelial lesions

Howard Strickler, J. Dillner, M. H. Schiffman, C. Eklund, A. G. Glass, C. Greer, D. R. Scott, M. E. Sherman, R. J. Kurman, M. Manos

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The seroepidemiology of genital human papillomavirus (HPV) and incident cervical squamous intraepithelial lesions (SIL) was studied in subjects selected from a large cohort monitored for the development of SIL. Serum IgG and IgA responses to 10 epitopes derived from HPV were measured in 21 incident cases of SIL and 56 matched controls. Cases showed elevated antibody (i.e., IgG and/or IgA) seroprevalence to 245:16, a peptide antigen derived from the E2 open reading frame of HPV 16 (OR = 5.76; 95% CI: 1.24, 26.81). The type of HPV DNA detected in cervical lavage specimens had no effect on this relationship. Multivariate analysis also showed that IgG to 245:6, an analogous peptide derived from HPV 6, was negatively associated with SIL (OR = 0.12; 95% CI: 0.02, 0.77). No other antibody responses tested were associated with SIL. Furthermore, no antibody responses were positively associated with detection of HPV DNA in women without SIL. We conclude that incident SIL is positively associated with antibody to an epitope derived from the E2 region of HPV 16, and negatively associated with antibody to an analogous peptide derived from HPV 6. The seroepidemiology of incident SIL appears different from that of cervical HPV infection in the absence of SIL.

Original languageEnglish (US)
Pages (from-to)169-177
Number of pages9
JournalViral Immunology
Volume7
Issue number4
StatePublished - 1994
Externally publishedYes

Fingerprint

Papillomavirus Infections
Seroepidemiologic Studies
Human papillomavirus 6
Human papillomavirus 16
Immunoglobulin G
Immunoglobulin A
Peptides
Antibody Formation
Antibodies
Epitopes
Squamous Intraepithelial Lesions of the Cervix
Therapeutic Irrigation
DNA
Open Reading Frames
Multivariate Analysis

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Strickler, H., Dillner, J., Schiffman, M. H., Eklund, C., Glass, A. G., Greer, C., ... Manos, M. (1994). A seroepidemiologic study of HPV infection and incident cervical squamous intraepithelial lesions. Viral Immunology, 7(4), 169-177.

A seroepidemiologic study of HPV infection and incident cervical squamous intraepithelial lesions. / Strickler, Howard; Dillner, J.; Schiffman, M. H.; Eklund, C.; Glass, A. G.; Greer, C.; Scott, D. R.; Sherman, M. E.; Kurman, R. J.; Manos, M.

In: Viral Immunology, Vol. 7, No. 4, 1994, p. 169-177.

Research output: Contribution to journalArticle

Strickler, H, Dillner, J, Schiffman, MH, Eklund, C, Glass, AG, Greer, C, Scott, DR, Sherman, ME, Kurman, RJ & Manos, M 1994, 'A seroepidemiologic study of HPV infection and incident cervical squamous intraepithelial lesions', Viral Immunology, vol. 7, no. 4, pp. 169-177.
Strickler H, Dillner J, Schiffman MH, Eklund C, Glass AG, Greer C et al. A seroepidemiologic study of HPV infection and incident cervical squamous intraepithelial lesions. Viral Immunology. 1994;7(4):169-177.
Strickler, Howard ; Dillner, J. ; Schiffman, M. H. ; Eklund, C. ; Glass, A. G. ; Greer, C. ; Scott, D. R. ; Sherman, M. E. ; Kurman, R. J. ; Manos, M. / A seroepidemiologic study of HPV infection and incident cervical squamous intraepithelial lesions. In: Viral Immunology. 1994 ; Vol. 7, No. 4. pp. 169-177.
@article{0014cebe48d64a0db3e725babfb61618,
title = "A seroepidemiologic study of HPV infection and incident cervical squamous intraepithelial lesions",
abstract = "The seroepidemiology of genital human papillomavirus (HPV) and incident cervical squamous intraepithelial lesions (SIL) was studied in subjects selected from a large cohort monitored for the development of SIL. Serum IgG and IgA responses to 10 epitopes derived from HPV were measured in 21 incident cases of SIL and 56 matched controls. Cases showed elevated antibody (i.e., IgG and/or IgA) seroprevalence to 245:16, a peptide antigen derived from the E2 open reading frame of HPV 16 (OR = 5.76; 95{\%} CI: 1.24, 26.81). The type of HPV DNA detected in cervical lavage specimens had no effect on this relationship. Multivariate analysis also showed that IgG to 245:6, an analogous peptide derived from HPV 6, was negatively associated with SIL (OR = 0.12; 95{\%} CI: 0.02, 0.77). No other antibody responses tested were associated with SIL. Furthermore, no antibody responses were positively associated with detection of HPV DNA in women without SIL. We conclude that incident SIL is positively associated with antibody to an epitope derived from the E2 region of HPV 16, and negatively associated with antibody to an analogous peptide derived from HPV 6. The seroepidemiology of incident SIL appears different from that of cervical HPV infection in the absence of SIL.",
author = "Howard Strickler and J. Dillner and Schiffman, {M. H.} and C. Eklund and Glass, {A. G.} and C. Greer and Scott, {D. R.} and Sherman, {M. E.} and Kurman, {R. J.} and M. Manos",
year = "1994",
language = "English (US)",
volume = "7",
pages = "169--177",
journal = "Viral Immunology",
issn = "0882-8245",
publisher = "Mary Ann Liebert Inc.",
number = "4",

}

TY - JOUR

T1 - A seroepidemiologic study of HPV infection and incident cervical squamous intraepithelial lesions

AU - Strickler, Howard

AU - Dillner, J.

AU - Schiffman, M. H.

AU - Eklund, C.

AU - Glass, A. G.

AU - Greer, C.

AU - Scott, D. R.

AU - Sherman, M. E.

AU - Kurman, R. J.

AU - Manos, M.

PY - 1994

Y1 - 1994

N2 - The seroepidemiology of genital human papillomavirus (HPV) and incident cervical squamous intraepithelial lesions (SIL) was studied in subjects selected from a large cohort monitored for the development of SIL. Serum IgG and IgA responses to 10 epitopes derived from HPV were measured in 21 incident cases of SIL and 56 matched controls. Cases showed elevated antibody (i.e., IgG and/or IgA) seroprevalence to 245:16, a peptide antigen derived from the E2 open reading frame of HPV 16 (OR = 5.76; 95% CI: 1.24, 26.81). The type of HPV DNA detected in cervical lavage specimens had no effect on this relationship. Multivariate analysis also showed that IgG to 245:6, an analogous peptide derived from HPV 6, was negatively associated with SIL (OR = 0.12; 95% CI: 0.02, 0.77). No other antibody responses tested were associated with SIL. Furthermore, no antibody responses were positively associated with detection of HPV DNA in women without SIL. We conclude that incident SIL is positively associated with antibody to an epitope derived from the E2 region of HPV 16, and negatively associated with antibody to an analogous peptide derived from HPV 6. The seroepidemiology of incident SIL appears different from that of cervical HPV infection in the absence of SIL.

AB - The seroepidemiology of genital human papillomavirus (HPV) and incident cervical squamous intraepithelial lesions (SIL) was studied in subjects selected from a large cohort monitored for the development of SIL. Serum IgG and IgA responses to 10 epitopes derived from HPV were measured in 21 incident cases of SIL and 56 matched controls. Cases showed elevated antibody (i.e., IgG and/or IgA) seroprevalence to 245:16, a peptide antigen derived from the E2 open reading frame of HPV 16 (OR = 5.76; 95% CI: 1.24, 26.81). The type of HPV DNA detected in cervical lavage specimens had no effect on this relationship. Multivariate analysis also showed that IgG to 245:6, an analogous peptide derived from HPV 6, was negatively associated with SIL (OR = 0.12; 95% CI: 0.02, 0.77). No other antibody responses tested were associated with SIL. Furthermore, no antibody responses were positively associated with detection of HPV DNA in women without SIL. We conclude that incident SIL is positively associated with antibody to an epitope derived from the E2 region of HPV 16, and negatively associated with antibody to an analogous peptide derived from HPV 6. The seroepidemiology of incident SIL appears different from that of cervical HPV infection in the absence of SIL.

UR - http://www.scopus.com/inward/record.url?scp=0028675823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028675823&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 169

EP - 177

JO - Viral Immunology

JF - Viral Immunology

SN - 0882-8245

IS - 4

ER -