A second BamHI DNA polymorphism and haplotype association in the factor IX gene

C. Driscoll, A. Dispenzieri, E. Tobias, C. H. Miller, L. M. Aledort

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A second BamHI DNA polymorphism has been identified in the factor IX gene in an American black population at an allelic frequency of 0.13. This site has been localized within 500 basepairs (bp) 5' to the XmnI intron 3 polymorphic site and increases the heterozygosity of black females at the factor IX gene locus. In addition, haplotype analysis of factor IX genes at five polymorphic loci indicates that although there is conservation of sequences between the races, factor IX genes show more heterogeneity in an American black population and thus more heterozygosity is observed in black females compared with whites. This increased heterogeneity is due to DNA polymorphisms unique to black populations and to linkage equilibrium between the most 5' and 3' polymorphic sites in factor IX genes in blacks.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalBlood
Volume72
Issue number1
StatePublished - 1988
Externally publishedYes

Fingerprint

Factor IX
Polymorphism
Haplotypes
Genes
DNA
Population
Introns
Conservation

ASJC Scopus subject areas

  • Hematology

Cite this

Driscoll, C., Dispenzieri, A., Tobias, E., Miller, C. H., & Aledort, L. M. (1988). A second BamHI DNA polymorphism and haplotype association in the factor IX gene. Blood, 72(1), 61-65.

A second BamHI DNA polymorphism and haplotype association in the factor IX gene. / Driscoll, C.; Dispenzieri, A.; Tobias, E.; Miller, C. H.; Aledort, L. M.

In: Blood, Vol. 72, No. 1, 1988, p. 61-65.

Research output: Contribution to journalArticle

Driscoll, C, Dispenzieri, A, Tobias, E, Miller, CH & Aledort, LM 1988, 'A second BamHI DNA polymorphism and haplotype association in the factor IX gene', Blood, vol. 72, no. 1, pp. 61-65.
Driscoll C, Dispenzieri A, Tobias E, Miller CH, Aledort LM. A second BamHI DNA polymorphism and haplotype association in the factor IX gene. Blood. 1988;72(1):61-65.
Driscoll, C. ; Dispenzieri, A. ; Tobias, E. ; Miller, C. H. ; Aledort, L. M. / A second BamHI DNA polymorphism and haplotype association in the factor IX gene. In: Blood. 1988 ; Vol. 72, No. 1. pp. 61-65.
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