A second BamHI DNA polymorphism and haplotype association in the factor IX gene

C. Driscoll; A. Dispenzieri; E. Tobias; C. H. Miller; L. M. Aledort

doi:10.1182/blood.v72.1.61.bloodjournal72161

A second BamHI DNA polymorphism and haplotype association in the factor IX gene

C. Driscoll, A. Dispenzieri, E. Tobias, C. H. Miller, L. M. Aledort

Pediatrics

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Abstract

A second BamHI DNA polymorphism has been identified in the factor IX gene in an American black population at an allelic frequency of 0.13. This site has been localized within 500 basepairs (bp) 5' to the XmnI intron 3 polymorphic site and increases the heterozygosity of black females at the factor IX gene locus. In addition, haplotype analysis of factor IX genes at five polymorphic loci indicates that although there is conservation of sequences between the races, factor IX genes show more heterogeneity in an American black population and thus more heterozygosity is observed in black females compared with whites. This increased heterogeneity is due to DNA polymorphisms unique to black populations and to linkage equilibrium between the most 5' and 3' polymorphic sites in factor IX genes in blacks.

Original language	English (US)
Pages (from-to)	61-65
Number of pages	5
Journal	Blood
Volume	72
Issue number	1
DOIs	https://doi.org/10.1182/blood.v72.1.61.bloodjournal72161
State	Published - 1988

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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title = "A second BamHI DNA polymorphism and haplotype association in the factor IX gene",

abstract = "A second BamHI DNA polymorphism has been identified in the factor IX gene in an American black population at an allelic frequency of 0.13. This site has been localized within 500 basepairs (bp) 5' to the XmnI intron 3 polymorphic site and increases the heterozygosity of black females at the factor IX gene locus. In addition, haplotype analysis of factor IX genes at five polymorphic loci indicates that although there is conservation of sequences between the races, factor IX genes show more heterogeneity in an American black population and thus more heterozygosity is observed in black females compared with whites. This increased heterogeneity is due to DNA polymorphisms unique to black populations and to linkage equilibrium between the most 5' and 3' polymorphic sites in factor IX genes in blacks.",

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T1 - A second BamHI DNA polymorphism and haplotype association in the factor IX gene

AU - Driscoll, C.

AU - Dispenzieri, A.

AU - Tobias, E.

AU - Miller, C. H.

AU - Aledort, L. M.

PY - 1988

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AB - A second BamHI DNA polymorphism has been identified in the factor IX gene in an American black population at an allelic frequency of 0.13. This site has been localized within 500 basepairs (bp) 5' to the XmnI intron 3 polymorphic site and increases the heterozygosity of black females at the factor IX gene locus. In addition, haplotype analysis of factor IX genes at five polymorphic loci indicates that although there is conservation of sequences between the races, factor IX genes show more heterogeneity in an American black population and thus more heterozygosity is observed in black females compared with whites. This increased heterogeneity is due to DNA polymorphisms unique to black populations and to linkage equilibrium between the most 5' and 3' polymorphic sites in factor IX genes in blacks.

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A second BamHI DNA polymorphism and haplotype association in the factor IX gene

Abstract

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