A search for a mucosal iron carrier. Identification of mucosal fractions with rapid turnover of Fe59

Simeon Pollack, Theresa Campana, Annette Arcario

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Abstract

Iron absorption by the intestinal mucosa, which is increased following phlebotomy, may be mediated by a carrier. A carrier for iron should show prompt uptake of iron introduced into the intestinal lumen and rapid transfer of the iron into the carcass. When iron absorption is increased movement of iron across the mucosa by this postulated carrier should take place at an accelerated rate. In an effort to identify mucosal fractions with these properties, the distribution of Fe59 between various fractions of guinea pig intestinal mucosa immediately after an intraluminal pulse of Fe59 was compared to the distribution of FE59 15 minutes after the pulse. Two mucosal fractions showing increased transfer of Fe59 to the carcass in animals with increased iron absorption were identified. It is proposed that these fractions participate in mucosal iron transport, whether as labile pools or carriers remains to be determined.

Original languageEnglish (US)
Pages (from-to)322-332
Number of pages11
JournalThe Journal of Laboratory and Clinical Medicine
Volume80
Issue number3
Publication statusPublished - Sep 1972

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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