A role for ferrous ion and oxygen in the degradation of DNA by bleomycin

Edward A. Sausville, Jack Peisach, Susan B. Horwitz

Research output: Contribution to journalArticle

274 Scopus citations

Abstract

An interaction between bleomycin and low concentrations of Fe(II) in the degradation of DNA is reported. Complete conversion of simian virus 40 DNA to acid-soluble products occurs at approximately equimolar levels of Fe(II), bleomycin, and DNA; Fe(III) does not substitute for Fe(II) in this reaction. Anaerobiosis inhibits the observed DNA degradation by bleomycin and Fe(II). Optical spectral studies reveal that an oxygen-labile complex is formed between bleomycin and Fe(II).

Original languageEnglish (US)
Pages (from-to)814-822
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume73
Issue number3
DOIs
StatePublished - Dec 6 1976

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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