TY - JOUR
T1 - A role for ferrous ion and oxygen in the degradation of DNA by bleomycin
AU - Sausville, Edward A.
AU - Peisach, Jack
AU - Horwitz, Susan B.
PY - 1976/12/6
Y1 - 1976/12/6
N2 - An interaction between bleomycin and low concentrations of Fe(II) in the degradation of DNA is reported. Complete conversion of simian virus 40 DNA to acid-soluble products occurs at approximately equimolar levels of Fe(II), bleomycin, and DNA; Fe(III) does not substitute for Fe(II) in this reaction. Anaerobiosis inhibits the observed DNA degradation by bleomycin and Fe(II). Optical spectral studies reveal that an oxygen-labile complex is formed between bleomycin and Fe(II).
AB - An interaction between bleomycin and low concentrations of Fe(II) in the degradation of DNA is reported. Complete conversion of simian virus 40 DNA to acid-soluble products occurs at approximately equimolar levels of Fe(II), bleomycin, and DNA; Fe(III) does not substitute for Fe(II) in this reaction. Anaerobiosis inhibits the observed DNA degradation by bleomycin and Fe(II). Optical spectral studies reveal that an oxygen-labile complex is formed between bleomycin and Fe(II).
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U2 - 10.1016/0006-291X(76)90882-2
DO - 10.1016/0006-291X(76)90882-2
M3 - Article
C2 - 64249
AN - SCOPUS:0017094368
SN - 0006-291X
VL - 73
SP - 814
EP - 822
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -