A receptor for the selective uptake and degradation of proteins by lysosomes

Ana Maria Cuervo, J. Fred Dice

Research output: Contribution to journalArticle

578 Scopus citations

Abstract

Multiple pathways of protein degradation operate within cells. A selective protein import pathway exists for the uptake and degradation of particular cytosolic proteins by lysosomes. Here, the lysosomal membrane glycoprotein LGP96 was identified as a receptor for the selective import and degradation of proteins within lysosomes. Specific substrates of this proteolytic pathway bound to the cytosolic tail of a 96-kilodalton lysosomal membrane protein in two different binding assays. Overexpression of human LGP96 in Chinese hamster ovary cells increased the activity of the selective lysosomal proteolytic pathway in vivo and in vitro.

Original languageEnglish (US)
Pages (from-to)501-503
Number of pages3
JournalScience
Volume273
Issue number5274
DOIs
StatePublished - Jul 26 1996
Externally publishedYes

ASJC Scopus subject areas

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