A Rare Presentation of Biclonal Gammopathy in Multiple Myeloma with Simultaneous Extramedullary Involvement: A Case Report

Pragnan Kancharla, Eshan Patel, Kenneth Hennrick, Sherif Ibrahim, Mendel Goldfinger

Research output: Contribution to journalArticle


Multiple myeloma is characterized by an abnormal clone of plasma cell infiltration in the bone marrow and presence of a high level monoclonal immunoglobulin (M-protein) in the serum or urine in most cases. The monoclonal protein is usually detected as a discrete band in the gamma globulin region by serum protein electrophoresis. Rarely, it may show a simultaneous presence of two distinct bands, which could be either from a single clone, or two separate clones. We report a very unusual presentation of biclonality with lambda restricted IgG predominant cells from cervical lymph node and kappa restricted IgA cells from the bone marrow simultaneously.

Original languageEnglish (US)
Pages (from-to)537-542
Number of pages6
JournalCase Reports in Oncology
Issue number2
Publication statusPublished - May 1 2019



  • Biclonal gammopathy
  • Extra medullary myeloma
  • Multiple myeloma

ASJC Scopus subject areas

  • Oncology

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